Literature DB >> 16950619

Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins.

Ali Koubeissi1, Imad Raad, Laurent Ettouati, David Guilet, Charles Dumontet, Joelle Paris.   

Abstract

Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins.

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Year:  2006        PMID： 16950619     DOI： 10.1016/j.bmcl.2006.07.059

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  ATP-binding cassette transporters modulate both coelenterazine- and D-luciferin-based bioluminescence imaging.

Authors:  Ruimin Huang; Jelena Vider; Inna Serganova; Ronald G Blasberg
Journal:  Mol Imaging       Date:  2011-06       Impact factor: 4.488

2.  P-glycoprotein acts as an immunomodulator during neuroinflammation.

Authors:  Gijs Kooij; Ronald Backer; Jasper J Koning; Arie Reijerkerk; Jack van Horssen; Susanne M A van der Pol; Joost Drexhage; Alfred Schinkel; Christine D Dijkstra; Joke M M den Haan; Teunis B H Geijtenbeek; Helga E de Vries
Journal:  PLoS One       Date:  2009-12-08       Impact factor: 3.240

3.  Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Authors:  Julica Nöth; Kevin J Frankowski; Benjamin Neuenswander; Jeffrey Aubé; Oliver Reiser
Journal:  J Comb Chem       Date:  2008-03-14

4.  Phosphinotripeptidic Inhibitors of Leucylaminopeptidases.

Authors:  Michał Jewgiński; Kinga Haremza; Jesús M de Los Santos; Zouhair Es Sbai; Bartosz Oszywa; Małgorzata Pawełczak; Francisco Palacios; Rafał Latajka
Journal:  Int J Mol Sci       Date:  2021-05-11       Impact factor: 5.923
  4 in total

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