Literature DB >> 15582415

Optimization of pyrrolidinone based HIV protease inhibitors.

Ronald G Sherrill1, C Webster Andrews, William J Bock, Ronda G Davis-Ward, Eric S Furfine, Richard J Hazen, Randy D Rutkowske, Andrew Spaltenstein, Lois L Wright.   

Abstract

Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.

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Year:  2005        PMID: 15582415     DOI: 10.1016/j.bmcl.2004.10.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Authors:  Arun K Ghosh; Heather L Osswald; Gary Prato
Journal:  J Med Chem       Date:  2016-01-22       Impact factor: 7.446

Review 2.  Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors.

Authors:  Arun K Ghosh; David D Anderson
Journal:  Future Med Chem       Date:  2011-07       Impact factor: 3.808

3.  Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Authors:  Julica Nöth; Kevin J Frankowski; Benjamin Neuenswander; Jeffrey Aubé; Oliver Reiser
Journal:  J Comb Chem       Date:  2008-03-14
  3 in total

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