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Literature DB >> 18338306

A fatal case of venlafaxine overdose.

George M Bosse¹, Henry A Spiller, Aaron M Collins.

Abstract

INTRODUCTION: Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects. CASE REPORT: A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QTC interval prolongation prior to his demise. DISCUSSION: A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 18338306 PMCID： PMC3550100 DOI： 10.1007/bf03160945

Source DB: PubMed Journal: J Med Toxicol ISSN： 1556-9039

12 in total

1. False-positive phencyclidine immunoassay results caused by venlafaxine and O-desmethylvenlafaxine.

Authors: Salvador F Sena; Syed Kazimi; Alan H B Wu
Journal: Clin Chem Date: 2002 Impact factor: 8.327

2. Isolated venlafaxine-induced serotonin syndrome.

Authors: P Kolecki
Journal: J Emerg Med Date: 1997 Jul-Aug Impact factor: 1.484

3. Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes.

Authors: M Khalifa; P Daleau; a J Turgeon
Journal: J Pharmacol Exp Ther Date: 1999-10 Impact factor: 4.030

4. Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants.

Authors: I M Whyte; A H Dawson; N A Buckley
Journal: QJM Date: 2003-05

5. Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans.

Authors: E Lessard; M A Yessine; B A Hamelin; G O'Hara; J LeBlanc; J Turgeon
Journal: Pharmacogenetics Date: 1999-08

6. Absolute bioavailability and electroencephalographic effects of conventional and extended-release formulations of venlafaxine in healthy subjects.

Authors: A Patat; S Troy; J Burke; S Trocherie; P Danjou; F Le Coz; H Allain; J M Gandon
Journal: J Clin Pharmacol Date: 1998-03 Impact factor: 3.126

Review 4. QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.

Authors: Mehrul Hasnain; W Victor R Vieweg
Journal: CNS Drugs Date: 2014-10 Impact factor: 5.749

5. A review of the suitability of duloxetine and venlafaxine for use in patients with depression in primary care with a focus on cardiovascular safety, suicide and mortality due to antidepressant overdose.

Authors: David Taylor; Alan Lenox-Smith; Andrew Bradley
Journal: Ther Adv Psychopharmacol Date: 2013-06

9. A comparative study of different electrodeposited NiCo₂O₄ microspheres anchored on a reduced graphene oxide platform: electrochemical sensor for anti-depressant drug venlafaxine.

Authors: Marwa F B Ali; Marwa R El-Zahry
Journal: RSC Adv Date: 2019-10-04 Impact factor: 4.036

10. Intralipid administration in case of a severe venlafaxine overdose in a patient with previous gastric bypass surgery.

Authors: D de Wit; E J F Franssen; N Verstoep
Journal: Toxicol Rep Date: 2022-05-17

10 in total

A fatal case of venlafaxine overdose.

1. False-positive phencyclidine immunoassay results caused by venlafaxine and O-desmethylvenlafaxine.

2. Isolated venlafaxine-induced serotonin syndrome.

3. Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes.

4. Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants.

5. Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans.

6. Absolute bioavailability and electroencephalographic effects of conventional and extended-release formulations of venlafaxine in healthy subjects.

7. A study involving venlafaxine overdoses: comparison of fatal and therapeutic concentrations in postmortem specimens.

8. Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine.

9. Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes.

10. Massive venlafaxine overdose resulted in a false positive Abbott AxSYM urine immunoassay for phencyclidine.

1. Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions.

Review 2. QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes.

3. A comparison of venlafaxine and SSRIs in deliberate self-poisoning.

Review 4. QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.

5. A review of the suitability of duloxetine and venlafaxine for use in patients with depression in primary care with a focus on cardiovascular safety, suicide and mortality due to antidepressant overdose.

6. Electrocardiogram changes and arrhythmias in venlafaxine overdose.

7. Cases of adverse reaction to psychotropic drugs and possible association with pharmacogenetics.

Review 8. Drugs and pharmaceuticals: management of intoxication and antidotes.

9. A comparative study of different electrodeposited NiCo₂O₄ microspheres anchored on a reduced graphene oxide platform: electrochemical sensor for anti-depressant drug venlafaxine.

10. Intralipid administration in case of a severe venlafaxine overdose in a patient with previous gastric bypass surgery.