Literature DB >> 9987886

A study involving venlafaxine overdoses: comparison of fatal and therapeutic concentrations in postmortem specimens.

P D Jaffe1, H P Batziris, P van der Hoeven, D DeSilva, I M McIntyre.   

Abstract

The distribution and redistribution of venlafaxine were investigated in two overdoses and several cases involving the therapeutic use of venlafaxine. Blood, liver, bile vitreous humor, urine and gastric contents were analyzed using high performance liquid chromatography with ultraviolet detection. Blood concentrations of venlafaxine in the two overdose cases were 53 mg/L and 78 mg/L. Comparison of venlafaxine concentrations in blood samples taken at different times after death revealed increases in concentrations over time, suggesting the possible postmortem redistribution of venlafaxine.

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Year:  1999        PMID： 9987886

Source DB:  PubMed          Journal:  J Forensic Sci        ISSN： 0022-1198            Impact factor:   1.832


  7 in total

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2.  A fatal case of venlafaxine overdose.

Authors:  George M Bosse; Henry A Spiller; Aaron M Collins
Journal:  J Med Toxicol       Date:  2008-03

3.  The effect of the postmortem interval on the redistribution of drugs: a comparison of mortuary admission and autopsy blood specimens.

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4.  Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions.

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Journal:  Int J Legal Med       Date:  2010-04-30       Impact factor: 2.686

Review 5.  The Black Book of Psychotropic Dosing and Monitoring.

Authors:  Alan F Schatzberg; DeBattista Charles
Journal:  Psychopharmacol Bull       Date:  2018-01-15

6.  Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases.

Authors:  L Karlsson; A-L Zackrisson; M Josefsson; B Carlsson; H Green; F C Kugelberg
Journal:  Pharmacogenomics J       Date:  2014-09-23       Impact factor: 3.550

7.  Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.

Authors:  Fabien Bévalot; Nathalie Cartiser; Charline Bottinelli; Laurent Fanton; Jérôme Guitton
Journal:  Forensic Toxicol       Date:  2015-10-28       Impact factor: 4.096
  7 in total

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