Confidence intervals for the overall effect size in random-effects meta-analysis.

One of the main objectives in meta-analysis is to estimate the overall effect size by calculating a confidence interval (CI). The usual procedure consists of assuming a standard normal distribution and a sampling variance defined as the inverse of the sum of the estimated weights of the effect sizes. But this procedure does not take into account the uncertainty due to the fact that the heterogeneity variance (tau2) and the within-study variances have to be estimated, leading to CIs that are too narrow with the consequence that the actual coverage probability is smaller than the nominal confidence level. In this article, the performances of 3 alternatives to the standard CI procedure are examined under a random-effects model and 8 different tau2 estimators to estimate the weights: the t distribution CI, the weighted variance CI (with an improved variance), and the quantile approximation method (recently proposed). The results of a Monte Carlo simulation showed that the weighted variance CI outperformed the other methods regardless of the tau2 estimator, the value of tau2, the number of studies, and the sample size.