Literature DB >> 18327973

Elevated substance P levels in HIV-infected women in comparison to HIV-negative women.

Steven D Douglas1, Avital Cnaan, Kevin G Lynch, Tami Benton, Huaqing Zhao, David R Gettes, Dwight L Evans.   

Abstract

Substance P and its receptor (neurokinin-1R) are potent modulators of neuroimmunoregulation and HIV/AIDS infection. We previously demonstrated that HIV-seropositive men had significantly higher substance P levels compared to uninfected controls. We now demonstrate that substance P plasma levels are significantly higher in HIV-infected women in comparison to uninfected control women.

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Year:  2008        PMID： 18327973     DOI： 10.1089/aid.2007.0207

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  18 in total

1.  Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals.

Authors:  Mark M Manak; Dmitry A Moshkoff; Lequan T Nguyen; John Meshki; Pablo Tebas; Florin Tuluc; Steven D Douglas
Journal:  AIDS       Date:  2010-11-27       Impact factor: 4.177

Review 2.  Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.

Authors:  Steven D Douglas; Susan E Leeman
Journal:  Ann N Y Acad Sci       Date:  2010-11-22       Impact factor: 5.691

Review 3.  Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.

Authors:  Susmit Suvas
Journal:  J Immunol       Date:  2017-09-01       Impact factor: 5.422

4.  Substance P-neurokinin-1 receptor interaction upregulates monocyte tissue factor.

Authors:  Mohammad M Khan; Steven D Douglas; Tami D Benton
Journal:  J Neuroimmunol       Date:  2011-11-23       Impact factor: 3.478

5.  Substance P-mediated chemokine production promotes monocyte migration.

Authors:  Sergei Spitsin; John Meshki; Angela Winters; Florin Tuluc; Tami D Benton; Steven D Douglas
Journal:  J Leukoc Biol       Date:  2016-10-21       Impact factor: 4.962

6.  HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P.

Authors:  Florin Tuluc; John Meshki; Sergei Spitsin; Steven D Douglas
Journal:  J Leukoc Biol       Date:  2014-02-27       Impact factor: 4.962

7.  Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology.

Authors:  Sergei Spitsin; Kathleen E Stevens; Steven D Douglas
Journal:  J Neurol Sci       Date:  2013-08-02       Impact factor: 3.181

8.  Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor.

Authors:  Lynnae Schwartz; Sergei V Spitsin; John Meshki; Florin Tuluc; Steven D Douglas; John H Wolfe
Journal:  J Neurovirol       Date:  2013-06-14       Impact factor: 2.643

9.  Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.

Authors:  Sergei Spitsin; Florin Tuluc; John Meshki; Jian Ping Lai; Richard Tustin Iii; Steven D Douglas
Journal:  Neuroimmunomodulation       Date:  2013-07-05       Impact factor: 2.492

10.  Neurokinin-1 receptor antagonist (aprepitant) suppresses HIV-1 infection of microglia/macrophages.

Authors:  Xu Wang; Steven D Douglas; Li Song; Yan-Jian Wang; Wen-Zhe Ho
Journal:  J Neuroimmune Pharmacol       Date:  2008-07-25       Impact factor: 4.147
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