| Literature DB >> 23765222 |
Lynnae Schwartz1, Sergei V Spitsin, John Meshki, Florin Tuluc, Steven D Douglas, John H Wolfe.
Abstract
The associations between the neurokinin-1 receptor (NK-1R), substance P (SP), and HIV-1 were investigated in neurosphere-derived cultures of microglial-depleted human fetal brain cells (HFBC). Full-length NK-1R was identified in HFBC cultures. SP treatment of the HFBC increased intracellular calcium mobilization and decreased electrical impedance, both of which were blocked by the NK-1R antagonist aprepitant. SP treatment of HIV-1-infected HFBC upregulated HIV-1 expression. These data show that human neural cells grown from neurospheres express functional full length NK-1R that is responsive to SP, and that SP enhanced HIV-1 infection in HBFC.Entities:
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Year: 2013 PMID： 23765222 PMCID： PMC3719168 DOI： 10.1007/s13365-013-0166-x
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643