Literature DB >> 28827386

Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.

Susmit Suvas1,2,3.   

Abstract

Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous system. SP released from the peripheral nerves exerts its biological and immunological activity via high-affinity neurokinin 1 receptor (NK1R). SP is also produced by immune cells and acts as an autocrine or paracrine fashion to regulate the function of immune cells. In addition to its proinflammatory role, SP and its metabolites in combination with insulin-like growth factor-1 are shown to promote the corneal epithelial wound healing. Recently, we showed an altered ocular surface homeostasis in unmanipulated NK1R-/- mice, suggesting the role of SP-NK1R signaling in ocular surface homeostasis under steady-state. This review summarizes the immunobiology of SP and its effect on immune cells and immunity to microbial infection. In addition, the effect of SP in inflammation, wound healing, and corneal epithelial homeostasis in the eye is discussed.
Copyright © 2017 by The American Association of Immunologists, Inc.

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Year:  2017        PMID： 28827386      PMCID： PMC5657331          DOI： 10.4049/jimmunol.1601751

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  183 in total

Review 1.  Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.

Authors:  Steven D Douglas; Susan E Leeman
Journal:  Ann N Y Acad Sci       Date:  2010-11-22       Impact factor: 5.691

2.  The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.

Authors:  K A DeFea; Z D Vaughn; E M O'Bryan; D Nishijima; O Déry; N W Bunnett
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

3.  Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence.

Authors:  Z Bar-Shavit; R Goldman; Y Stabinsky; P Gottlieb; M Fridkin; V I Teichberg; S Blumberg
Journal:  Biochem Biophys Res Commun       Date:  1980-06-30       Impact factor: 3.575

4.  Neurokinin-1 receptor, a new modulator of lymphangiogenesis in obese-asthma phenotype.

Authors:  Renata Ramalho; Joana Almeida; Rubén Fernandes; Raquel Costa; Ana Pirraco; Luísa Guardão; Luís Delgado; André Moreira; Raquel Soares
Journal:  Life Sci       Date:  2013-06-20       Impact factor: 5.037

5.  Impaired IL-1beta-induced neutrophil accumulation in tachykinin NK1 receptor knockout mice.

Authors:  A Ahluwalia; C De Felipe; J O'Brien; S P Hunt; M Perretti
Journal:  Br J Pharmacol       Date:  1998-07       Impact factor: 8.739

Review 6.  The role of tachykinins on bacterial infections.

Authors:  David W Pascual
Journal:  Front Biosci       Date:  2004-09-01

7.  Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor.

Authors:  G A Cook; D Elliott; A Metwali; A M Blum; M Sandor; R Lynch; J V Weinstock
Journal:  J Immunol       Date:  1994-02-15       Impact factor: 5.422

8.  Endogenous substance P in corneal epithelial cells and keratocytes.

Authors:  Michifumi Watanabe; Kiyo Nakayasu; Minoru Iwatsu; Atsushi Kanai
Journal:  Jpn J Ophthalmol       Date:  2002 Nov-Dec       Impact factor: 2.447

9.  Human lymphocytes express substance P and its receptor.

Authors:  J P Lai; S D Douglas; W Z Ho
Journal:  J Neuroimmunol       Date:  1998-06-01       Impact factor: 3.478

10.  IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.

Authors:  Theoharis C Theoharides; Bodi Zhang; Duraisamy Kempuraj; Michael Tagen; Magdalini Vasiadi; Asimenia Angelidou; Konstantinos-Dionysios Alysandratos; Dimitris Kalogeromitros; Shahrzad Asadi; Nikolaos Stavrianeas; Erika Peterson; Susan Leeman; Pio Conti
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205
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  73 in total

1.  A Proximal Culture Method to Study Paracrine Signaling Between Cells.

Authors:  Subramanyam Dasari; Taruni Pandhiri; James Haley; Dean Lenz; Anirban K Mitra
Journal:  J Vis Exp       Date:  2018-08-28       Impact factor: 1.355

2.  Reply to Fattori et al.: Action of SP and IL-33 on mast cells.

Authors:  Theoharis C Theoharides; Alexandra Taracanova; Irene Tsilioni; Pio Conti; Susan E Leeman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-06       Impact factor: 11.205

3.  Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas.

Authors:  Yangyang Zhang; Nan Gao; Lin Wu; Patrick S Y Lee; Rao Me; Chenyang Dai; Lixin Xie; Fu-Shin X Yu
Journal:  Diabetes       Date:  2020-04-28       Impact factor: 9.461

4.  Increased Substance P Immunoreactivity in Ipsilateral Knee Cartilage of Rats Exposed to Lumbar Spine Injury.

Authors:  Felipe C K Duarte; Derek P Zwambag; Stephen H M Brown; Andrea Clark; Mark Hurtig; John Z Srbely
Journal:  Cartilage       Date:  2018-11-21       Impact factor: 4.634

5.  Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury.

Authors:  Elsayed Elbasiony; Sharad K Mittal; William Foulsham; WonKyung Cho; Sunil K Chauhan
Journal:  Ocul Surf       Date:  2020-06-29       Impact factor: 5.033

6.  Evaluation of serum level of substance P and tissue distribution of NK-1 receptor in breast cancer.

Authors:  Monireh Davoodian; Nadia Boroumand; Mostafa Mehrabi Bahar; Amir Hosein Jafarian; Mahdi Asadi; Seyed Isaac Hashemy
Journal:  Mol Biol Rep       Date:  2019-01-25       Impact factor: 2.316

7.  Sensory Nociceptive Neurons Contribute to Host Protection During Enteric Infection With Citrobacter rodentium.

Authors:  Valerie T Ramirez; Jessica Sladek; Dayn Romero Godinez; Kavi M Rude; Pamela Chicco; Kaitlin Murray; Ingrid Brust-Mascher; Melanie G Gareau; Colin Reardon
Journal:  J Infect Dis       Date:  2020-06-11       Impact factor: 5.226

Review 8.  Interactions of the immune and sensory nervous systems in atopy.

Authors:  Landon K Oetjen; Brian S Kim
Journal:  FEBS J       Date:  2018-04-30       Impact factor: 5.542

9.  Neuropeptide Substance P Enhances Inflammation-Mediated Tumor Signaling Pathways and Migration and Proliferation of Head and Neck Cancers.

Authors:  Sumeet Singh; Subhashree Kumaravel; Saurabh Dhole; Sukanya Roy; Vani Pavan; Sanjukta Chakraborty
Journal:  Indian J Surg Oncol       Date:  2020-09-01

Review 10.  Function of peripheral nerves in the development and healing of tendon and bone.

Authors:  Ibtesam Rajpar; Ryan E Tomlinson
Journal:  Semin Cell Dev Biol       Date:  2021-05-13       Impact factor: 7.727
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