| Literature DB >> 18325485 |
Dmitry Tikhonravov1, Tuomas Neuvonen, Antti Pertovaara, Kati Savioja, Timo Ruusuvirta, Risto Näätänen, Synnöve Carlson.
Abstract
In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N-methyl-d-aspartate (NMDA) receptors have a central role in the generation of the MMN. MMN-like responses have also been recorded in other animals, including rats. The present study aimed at determining whether the MMN-like response in rats depends on an intact NMDA-receptor system. We recorded auditory evoked responses during an oddball paradigm epidurally in anesthetized rats that had received intraperitoneal injections of saline or an NMDA-receptor antagonist MK-801. An MMN-like response was recorded in the oddball paradigm in saline-treated rats. Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system.Entities:
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Year: 2008 PMID： 18325485 DOI： 10.1016/j.brainres.2008.02.006
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252