Anna Bravermanová1,2, Michaela Viktorinová1,3, Filip Tylš1,3, Tomáš Novák1,3, Renáta Androvičová1,3, Jakub Korčák1,3, Jiří Horáček1,3, Marie Balíková2, Inga Griškova-Bulanova4, Dominika Danielová1,3, Přemysl Vlček1,3, Pavel Mohr1,3, Martin Brunovský1,3, Vlastimil Koudelka1, Tomáš Páleníček5,6. 1. National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic. 2. First Faculty of Medicine, Charles University Prague, Kateřinská 32, 121 08, Prague 2, Czech Republic. 3. Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Praha 10, Czech Republic. 4. Institute of Biosciences, Vilnius University, Sauletekio ave 7, 102 57, Vilnius, Lithuania. 5. National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic. tomas.palenicek@nudz.cz. 6. Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Praha 10, Czech Republic. tomas.palenicek@nudz.cz.
Abstract
RATIONALE: Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-HT2A receptors in information processing is less clear. OBJECTIVES: We studied ERPs in a serotonergic model of psychosis, induced by psilocybin, a psychedelic with 5-HT2A/C agonistic properties, in healthy volunteers. METHODS:Twenty subjects (10M/10F) were given 0.26 mg/kg of psilocybin orally in a placebo-controlled, double-blind, cross-over design. ERPs (P300, MMN) were registered during the peak of intoxication. Correlations between measured electrophysiological variables and psilocin serum levels and neuropsychological effects were also analyzed. RESULTS:Psilocybin induced robust psychedelic effects and psychotic-like symptoms, decreased P300 amplitude (p = 0.009) but did not affect the MMN. Psilocybin's disruptive effect on P300 correlated with the intensity of the psychedelic state, which was dependent on the psilocin serum levels. We also observed a decrease in N100 amplitude (p = 0.039) in the P300 paradigm and a negative correlation between P300 and MMN amplitude (p = 0.014). CONCLUSIONS: Even though pre-attentive cognition (MMN) was not affected, processing at the early perceptual level (N100) and in higher-order cognition (P300) was significantly disrupted by psilocybin. Our results have implications for the role of 5-HT2A receptors in altered information processing in psychosis and schizophrenia.
RCT Entities:
RATIONALE: Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-HT2A receptors in information processing is less clear. OBJECTIVES: We studied ERPs in a serotonergic model of psychosis, induced by psilocybin, a psychedelic with 5-HT2A/C agonistic properties, in healthy volunteers. METHODS: Twenty subjects (10M/10F) were given 0.26 mg/kg of psilocybin orally in a placebo-controlled, double-blind, cross-over design. ERPs (P300, MMN) were registered during the peak of intoxication. Correlations between measured electrophysiological variables and psilocin serum levels and neuropsychological effects were also analyzed. RESULTS: Psilocybin induced robust psychedelic effects and psychotic-like symptoms, decreased P300 amplitude (p = 0.009) but did not affect the MMN. Psilocybin's disruptive effect on P300 correlated with the intensity of the psychedelic state, which was dependent on the psilocin serum levels. We also observed a decrease in N100 amplitude (p = 0.039) in the P300 paradigm and a negative correlation between P300 and MMN amplitude (p = 0.014). CONCLUSIONS: Even though pre-attentive cognition (MMN) was not affected, processing at the early perceptual level (N100) and in higher-order cognition (P300) was significantly disrupted by psilocybin. Our results have implications for the role of 5-HT2A receptors in altered information processing in psychosis and schizophrenia.
Entities:
Keywords:
ERP; Human; MMN; Model of psychosis; P300; Psilocybin
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