Literature DB >> 18321552

Can one learn history from the allelic spectrum?

Simon Myers1, Charles Fefferman, Nick Patterson.   

Abstract

It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.

Mesh:

Year:  2008        PMID: 18321552     DOI: 10.1016/j.tpb.2008.01.001

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  47 in total

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