Literature DB >> 18320008

Dioxadispiroketal Compounds and a Potential Acyclic Precursor from Amomum aculeatum.

Angela A Salim1, Bao-Ning Su, Hee-Byung Chai, Soedarsono Riswan, Leonardus B S Kardono, Agus Ruskandi, Norman R Farnsworth, Steven M Swanson, A Douglas Kinghorn.   

Abstract

Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1-4), their potential precursor, 5R-hydroxy-1-(4-hydroxyl-phenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1-4, 6 and 7 showed cytotoxic activity against several human cancer cell lines.

Entities:  

Year:  2007        PMID： 18320008      PMCID： PMC1950142          DOI： 10.1016/j.tetlet.2007.01.017

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  5 in total

1.  Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.

Authors:  E K Seo; N C Kim; Q Mi; H Chai; M E Wall; M C Wani; H A Navarro; J P Burgess; J G Graham; F Cabieses; G T Tan; N R Farnsworth; J M Pezzuto; A D Kinghorn
Journal:  J Nat Prod       Date:  2001-11       Impact factor: 4.050

2.  Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum.

Authors:  J Heilmann; R Brun; S Mayr; T Rali; O Sticher
Journal:  Phytochemistry       Date:  2001-08       Impact factor: 4.072

3.  Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis.

Authors:  Bao-Ning Su; Young-Hwa Kang; Rosa Elena Pinos; Bernard D Santarsiero; Andrew D Mesecar; D Doel Soejarto; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Journal:  Phytochemistry       Date:  2003-09       Impact factor: 4.072

4.  Cardiotonic principles of ginger (Zingiber officinale Roscoe).

Authors:  N Shoji; A Iwasa; T Takemoto; Y Ishida; Y Ohizumi
Journal:  J Pharm Sci       Date:  1982-10       Impact factor: 3.534

5.  New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes.

Authors:  Bao-Ning Su; Eun Jung Park; Zakaria H Mbwambo; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; John M Pezzuto; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2002-09       Impact factor: 4.050
  5 in total
  6 in total

Review 1.  The relevance of higher plants in lead compound discovery programs.

Authors:  A Douglas Kinghorn; Li Pan; Joshua N Fletcher; Heebyung Chai
Journal:  J Nat Prod       Date:  2011-06-08       Impact factor: 4.050

2.  Polyol synthesis with beta-oxyanionic alkyllithium reagents: syntheses of aculeatins A, B, and D.

Authors:  Viengkham Malathong; Scott D Rychnovsky
Journal:  Org Lett       Date:  2009-09-17       Impact factor: 6.005

3.  Discovery of anticancer agents of diverse natural origin.

Authors:  A Douglas Kinghorn; Esperanza J Carcache de Blanco; Hee-Byung Chai; Jimmy Orjala; Norman R Farnsworth; D Doel Soejarto; Nicholas H Oberlies; Mansukh C Wani; David J Kroll; Cedric J Pearce; Steven M Swanson; Robert A Kramer; William C Rose; Craig R Fairchild; Gregory D Vite; Stuart Emanuel; David Jarjoura; Frederick O Cope
Journal:  Pure Appl Chem       Date:  2009-01-01       Impact factor: 2.453

4.  Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.

Authors:  Young-Won Chin; Angela A Salim; Bao-Ning Su; Qiuwen Mi; Hee-Byung Chai; Soedarsono Riswan; Leonardus B S Kardono; Agus Ruskandi; Norman R Farnsworth; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2008-02-09       Impact factor: 4.050

Review 5.  Recent synthetic approaches toward non-anomeric spiroketals in natural products.

Authors:  Sylvain Favre; Pierre Vogel; Sandrine Gerber-Lemaire
Journal:  Molecules       Date:  2008       Impact factor: 4.411

6.  Methylated Flavonols from Amomum koenigii J.F.Gmel. and Their Antimicrobial and Antioxidant Activities.

Authors:  Minh Giang Phan; Thi Viet Huong Do; Quoc Binh Nguyen
Journal:  Biochem Res Int       Date:  2020-02-18
  6 in total

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