Literature DB >> 20046887

Discovery of anticancer agents of diverse natural origin.

A Douglas Kinghorn1, Esperanza J Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R Farnsworth, D Doel Soejarto, Nicholas H Oberlies, Mansukh C Wani, David J Kroll, Cedric J Pearce, Steven M Swanson, Robert A Kramer, William C Rose, Craig R Fairchild, Gregory D Vite, Stuart Emanuel, David Jarjoura, Frederick O Cope.   

Abstract

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.

Entities:  

Year:  2009        PMID： 20046887      PMCID： PMC2765058          DOI： 10.1351/PAC-CON-08-10-16

Source DB:  PubMed          Journal:  Pure Appl Chem        ISSN： 0033-4545            Impact factor:   2.453


  70 in total

Review 1.  Bioactive compounds from cyanobacteria and microalgae: an overview.

Authors:  Sawraj Singh; Bhushan N Kate; U C Banerjee
Journal:  Crit Rev Biotechnol       Date:  2005 Jul-Sep       Impact factor: 8.429

2.  Enhanced antimalarial activity of novel synthetic aculeatin derivatives.

Authors:  Marine Peuchmaur; Nadia Saïdani; Cyrille Botté; Eric Maréchal; Henri Vial; Yung-Sing Wong
Journal:  J Med Chem       Date:  2008-08-05       Impact factor: 7.446

3.  In vivo model development of cisplatin-resistant and -sensitive A2780 human ovarian carcinomas.

Authors:  W C Rose; G A Basler
Journal:  In Vivo       Date:  1990 Nov-Dec       Impact factor: 2.155

4.  Correlation of in vitro cytotoxicity with preclinical in vivo antitumor activity.

Authors:  W C Rose; J E Schurig; J B Meeker
Journal:  Anticancer Res       Date:  1988 May-Jun       Impact factor: 2.480

5.  Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project.

Authors:  Marcy J Balunas; William P Jones; Young-Won Chin; Qiuwen Mi; Norman R Farnsworth; Djaja D Soejarto; Geoffrey A Cordell; Steven M Swanson; John M Pezzuto; Hee-Byung Chai; A Douglas Kinghorn
Journal:  Chem Biodivers       Date:  2006-08       Impact factor: 2.408

Review 6.  The NCI60 human tumour cell line anticancer drug screen.

Authors:  Robert H Shoemaker
Journal:  Nat Rev Cancer       Date:  2006-10       Impact factor: 60.716

7.  The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.

Authors:  Thomas J Turbyville; E M Kithsiri Wijeratne; Luke Whitesell; A A Leslie Gunatilaka
Journal:  Mol Cancer Ther       Date:  2005-10       Impact factor: 6.261

8.  Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Authors:  Sharnelle S Phifer; Dongho Lee; Eun-Kyoung Seo; Nam-Cheol Kim; Tyler N Graf; David J Kroll; Hernan A Navarro; Robert A Izydore; Francisco Jiménez; Ricardo Garcia; William C Rose; Craig R Fairchild; Robert Wild; Djaja D Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Nicholas H Oberlies; Monroe E Wall; Mansukh C Wani
Journal:  J Nat Prod       Date:  2007-06-07       Impact factor: 4.050

9.  Dioxadispiroketal Compounds and a Potential Acyclic Precursor from Amomum aculeatum.

Authors:  Angela A Salim; Bao-Ning Su; Hee-Byung Chai; Soedarsono Riswan; Leonardus B S Kardono; Agus Ruskandi; Norman R Farnsworth; Steven M Swanson; A Douglas Kinghorn
Journal:  Tetrahedron Lett       Date:  2007-03-05       Impact factor: 2.415

10.  Alvaradoins A-D. Anthracenone C arabinosides from alvaradoa jamaicensis

Authors: 
Journal:  J Nat Prod       Date:  1999-01       Impact factor: 4.050
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  55 in total

1.  Investigation of Vietnamese plants for potential anticancer agents.

Authors:  Lynette Bueno Pérez; Patrick C Still; C Benjamin Naman; Yulin Ren; Li Pan; Hee-Byung Chai; Esperanza J Carcache de Blanco; Tran Ngoc Ninh; Bui Van Thanh; Steven M Swanson; Djaja D Soejarto; A Douglas Kinghorn
Journal:  Phytochem Rev       Date:  2014-12       Impact factor: 5.374

2.  Phytochemical and Bioactivity Studies on Constituents of the Leaves of Vitex Quinata.

Authors:  Ye Deng; Young-Won Chin; Hee-Byung Chai; Esperanza Carcache de Blanco; Leonardus B S Kardono; Soedarsano Riswan; Djaja D Soejarto; Norman R Farnsworth; A Douglas Kinghorn
Journal:  Phytochem Lett       Date:  2011-09-01       Impact factor: 1.679

3.  Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens.

Authors:  Yulin Ren; Ulyana Muñoz Acuña; Francisco Jiménez; Ricardo García; Melciades Mejía; Heebyung Chai; Judith C Gallucci; Norman R Farnsworth; Djaja D Soejarto; Esperanza J Carcache de Blanco; A Douglas Kinghorn
Journal:  Tetrahedron       Date:  2012-01-26       Impact factor: 2.457

4.  A cytotoxic decahydronaphthalenylpropenal derivative and tetrahydrofuran lignans from the stems of Cameraria latifolia.

Authors:  Yulin Ren; Heebyung Chai; Michael Goetz; A Douglas Kinghorn
Journal:  Tetrahedron Lett       Date:  2013-09-04       Impact factor: 2.415

5.  Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.

Authors:  Yulin Ren; Susan Matthew; Daniel D Lantvit; Tran Ngoc Ninh; Heebyung Chai; James R Fuchs; Djaja D Soejarto; Esperanza J Carcache de Blanco; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2011-03-23       Impact factor: 4.050

Review 6.  Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones.

Authors:  Yulin Ren; Jianhua Yu; A Douglas Kinghorn
Journal:  Curr Med Chem       Date:  2016       Impact factor: 4.530

Review 7.  The relevance of higher plants in lead compound discovery programs.

Authors:  A Douglas Kinghorn; Li Pan; Joshua N Fletcher; Heebyung Chai
Journal:  J Nat Prod       Date:  2011-06-08       Impact factor: 4.050

8.  Potential Anticancer Agents Characterized from Selected Tropical Plants.

Authors:  Yulin Ren; Esperanza J Carcache de Blanco; James R Fuchs; Djaja D Soejarto; Joanna E Burdette; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2019-03-04       Impact factor: 4.050

9.  Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.

Authors:  Mario Figueroa; Tyler N Graf; Sloan Ayers; Audrey F Adcock; David J Kroll; Jilai Yang; Steven M Swanson; Ulyana Munoz-Acuna; Esperanza J Carcache de Blanco; Rajesh Agrawal; Mansukh C Wani; Blaise A Darveaux; Cedric J Pearce; Nicholas H Oberlies
Journal:  J Antibiot (Tokyo)       Date:  2012-09-12       Impact factor: 2.649

10.  Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).

Authors:  Ah-Reum Han; Jeong-Ah Kim; Daniel D Lantvit; Leonardus B S Kardono; Soedarsono Riswan; Heebyung Chai; Esperanza J Carcache de Blanco; Norman R Farnsworth; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2009-11       Impact factor: 4.050
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