Literature DB >> 11720542

Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.

E K Seo1, N C Kim, Q Mi, H Chai, M E Wall, M C Wani, H A Navarro, J P Burgess, J G Graham, F Cabieses, G T Tan, N R Farnsworth, J M Pezzuto, A D Kinghorn.   

Abstract

A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.

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Year:  2001        PMID： 11720542     DOI： 10.1021/np0103158

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  22 in total

1.  Phytochemical and Bioactivity Studies on Constituents of the Leaves of Vitex Quinata.

Authors:  Ye Deng; Young-Won Chin; Hee-Byung Chai; Esperanza Carcache de Blanco; Leonardus B S Kardono; Soedarsano Riswan; Djaja D Soejarto; Norman R Farnsworth; A Douglas Kinghorn
Journal:  Phytochem Lett       Date:  2011-09-01       Impact factor: 1.679

2.  Prenylated flavonoids from the root bark of Berchemia discolor, a Tanzanian medicinal plant.

Authors:  Young-Won Chin; Ladislaus K Mdee; Zakaria H Mbwambo; Qiuwen Mi; Hee-Byung Chai; Gordon M Cragg; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2006-11       Impact factor: 4.050

3.  Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.

Authors:  William P Jones; Tatiana Lobo-Echeverri; Qiuwen Mi; Hee-Byung Chai; Djaja D Soejarto; Geoffrey A Cordell; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2007-02-06       Impact factor: 4.050

Review 4.  Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Authors:  Garima Agarwal; Peter J Blanco Carcache; Ermias Mekuria Addo; A Douglas Kinghorn
Journal:  Biotechnol Adv       Date:  2019-01-08       Impact factor: 14.227

5.  Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii.

Authors:  Aleksej Krunic; Armelle Vallat; Shunyan Mo; Daniel D Lantvit; Steven M Swanson; Jimmy Orjala
Journal:  J Nat Prod       Date:  2010-11-08       Impact factor: 4.050

6.  Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

Authors:  Yulin Ren; Leonardus B S Kardono; Soedarsono Riswan; Heebyung Chai; Norman R Farnsworth; Djaja D Soejarto; Esperanza J Carcache de Blanco; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

7.  Cytotoxic flavaglines and bisamides from Aglaia edulis.

Authors:  Soyoung Kim; Young-Won Chin; Bao-Ning Su; Soedarsono Riswan; Leonardus B S Kardono; Johar J Afriastini; Heebyung Chai; Norman R Farnsworth; Geoffrey A Cordell; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2006-12       Impact factor: 4.050

8.  Ponapensin, a cyclopenta[bc]benzopyran with potent NF-kappaB inhibitory activity from Aglaia ponapensis.

Authors:  Angela A Salim; Alison D Pawlus; Hee-Byung Chai; Norman R Farnsworth; A Douglas Kinghorn; Esperanza J Carcache-Blanco
Journal:  Bioorg Med Chem Lett       Date:  2006-09-30       Impact factor: 2.823

9.  Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.

Authors:  Liqiong Fang; Aiko Ito; Hee-Byung Chai; Qiuwen Mi; William P Jones; Domingo R Madulid; Mildred B Oliveros; Qi Gao; Jimmy Orjala; Norman R Farnsworth; Djaja D Soejarto; Geoffrey A Cordell; Steven M Swanson; John M Pezzuto; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2006-03       Impact factor: 4.050

10.  Constituents of the Leaves and Stem Bark of Aglaia foveolata.

Authors:  Angela A Salim; Hee-Byung Chai; Ismail Rachman; Soedarsono Riswan; Leonardus B S Kardono; Norman R Farnsworth; Esperanza J Carcache-Blanco; A Douglas Kinghorn
Journal:  Tetrahedron       Date:  2007-08-13       Impact factor: 2.457
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