Literature DB >> 18316083

Pharmacological agents and impairment of fracture healing: what is the evidence?

Ippokratis Pountos1, Theodora Georgouli, Taco J Blokhuis, Hans Chistoph Pape, Peter V Giannoudis.   

Abstract

Bone healing is an extremely complex process which depends on the coordinated action of several cell lineages on a cascade of biological events, and has always been a major medical concern. The use of several drugs such as corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity have been shown to affect bone healing. This review article presents our current understanding on this topic, focusing on data illustrating the effect of these drugs on fracture healing and bone regeneration.

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Year:  2008        PMID： 18316083     DOI： 10.1016/j.injury.2007.10.035

Source DB:  PubMed          Journal:  Injury        ISSN： 0020-1383            Impact factor:   2.586


  28 in total

1.  Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer.

Authors:  Gabriel M Pagnotti; Benjamin J Adler; Danielle E Green; M Ete Chan; Danielle M Frechette; Kenneth R Shroyer; Wesley G Beamer; Janet Rubin; Clinton T Rubin
Journal:  Bone       Date:  2012-05-11       Impact factor: 4.398

2.  Multiple roles for CCR2 during fracture healing.

Authors:  Zhiqing Xing; Chuanyong Lu; Diane Hu; Yan-yiu Yu; Xiaodong Wang; Celine Colnot; Mary Nakamura; Yalei Wu; Theodore Miclau; Ralph S Marcucio
Journal:  Dis Model Mech       Date:  2010-03-30       Impact factor: 5.758

Review 3.  Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing.

Authors:  Cheng Cheng; Dolores Shoback
Journal:  Curr Osteoporos Rep       Date:  2019-02       Impact factor: 5.096

4.  Pharmacological agents and bone healing.

Authors:  Umberto Tarantino; Irene Cerocchi; Monica Celi; Alessandro Scialdoni; Luca Saturnino; Elena Gasbarra
Journal:  Clin Cases Miner Bone Metab       Date:  2009-05

Review 5.  Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence today.

Authors:  Ippokratis Pountos; Theodora Georgouli; George Kontakis; Peter V Giannoudis
Journal:  Int Orthop       Date:  2010-02       Impact factor: 3.075

6.  Assessment of SiCaP-30 in a Rabbit Posterolateral Fusion Model with Concurrent Chemotherapy.

Authors:  Joseph D Smucker; Emily B Petersen; Ali Al-Hili; James V Nepola; Douglas C Fredericks
Journal:  Iowa Orthop J       Date:  2015

7.  The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study.

Authors:  Mujgan Gungor Hatipoglu; Sermet Inal; Sahin Kabay; Muhammet Kasim Cayci; Ayşenur Deger; Halil Isa Kuru; Sayit Altikat; Gizem Akkas
Journal:  Acta Stomatol Croat       Date:  2015-12

8.  Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats' critical-sized mandibular defects.

Authors:  Muhammad A Awadeen; Fouad A Al-Belasy; Laila E Ameen; Mohamad E Helal; Mohammed E Grawish
Journal:  World J Stem Cells       Date:  2020-01-26       Impact factor: 5.326

Review 9.  Orthopaedic surgeons' strategies in pharmacological treatment of fragility fractures.

Authors:  Antonio Capone; Francesca Orgiano; Francesca Pianu; Marco Planta
Journal:  Clin Cases Miner Bone Metab       Date:  2014-05

10.  Serum proteomic assessment of the progression of fracture healing.

Authors:  Amira I Hussein; Christian Mancini; Kyle E Lybrand; Margaret E Cooke; Heather E Matheny; Brenna L Hogue; Paul Tornetta; Louis C Gerstenfeld
Journal:  J Orthop Res       Date:  2017-11-22       Impact factor: 3.494
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