Literature DB >> 1831490

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

H Yssel1, M C Shanafelt, C Soderberg, P V Schneider, J Anzola, G Peltz.   

Abstract

18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.

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Year:  1991        PMID： 1831490      PMCID： PMC2118948          DOI： 10.1084/jem.174.3.593

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  37 in total

1.  Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.

Authors:  E Fikrig; S W Barthold; F S Kantor; R A Flavell
Journal:  Science       Date:  1990-10-26       Impact factor: 47.728

Review 2.  Functional diversity of T lymphocytes due to secretion of different cytokine patterns.

Authors:  N E Street; T R Mosmann
Journal:  FASEB J       Date:  1991-02       Impact factor: 5.191

3.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver.

Authors:  U E Schaible; S Gay; C Museteanu; M D Kramer; G Zimmer; K Eichmann; U Museteanu; M M Simon
Journal:  Am J Pathol       Date:  1990-10       Impact factor: 4.307

5.  Lyme disease-a tick-borne spirochetosis?

Authors:  W Burgdorfer; A G Barbour; S F Hayes; J L Benach; E Grunwaldt; J P Davis
Journal:  Science       Date:  1982-06-18       Impact factor: 47.728

6.  Analysis of T lymphocytes cloned from the synovial fluid and blood of a patient with Lyme arthritis.

Authors:  H Yssel; T Nakamoto; P Schneider; V Freitas; C Collins; D Webb; N Mensi; C Soderberg; G Peltz
Journal:  Int Immunol       Date:  1990       Impact factor: 4.823

7.  T cell and antibody reactivity with the Borrelia burgdorferi 60-kDa heat shock protein in Lyme arthritis.

Authors:  M C Shanafelt; P Hindersson; C Soderberg; N Mensi; C W Turck; D Webb; H Yssel; G Peltz
Journal:  J Immunol       Date:  1991-06-01       Impact factor: 5.422

8.  Immunoreactive epitopes on an expressed recombinant flagellar protein of Borrelia burgdorferi.

Authors:  C Collins; G Peltz
Journal:  Infect Immun       Date:  1991-02       Impact factor: 3.441

9.  Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

Authors:  D B Lewis; C C Yu; J Meyer; B K English; S J Kahn; C B Wilson
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808

10.  A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

Authors:  R Martin; M D Howell; D Jaraquemada; M Flerlage; J Richert; S Brostoff; E O Long; D E McFarlin; H F McFarland
Journal:  J Exp Med       Date:  1991-01-01       Impact factor: 14.307
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  75 in total

Review 1.  Induction of T helper cell subsets.

Authors:  M Röcken; K M Müller; C Hauser
Journal:  Springer Semin Immunopathol       Date:  1992

2.  Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis.

Authors:  Shiqian Shen; Junghee J Shin; Klemen Strle; Gail McHugh; Xin Li; Lisa J Glickstein; Elise E Drouin; Allen C Steere
Journal:  Arthritis Rheum       Date:  2010-07

Review 3.  Host-pathogen interactions in the immunopathogenesis of Lyme disease.

Authors:  L T Hu; M S Klempner
Journal:  J Clin Immunol       Date:  1997-09       Impact factor: 8.317

4.  Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism.

Authors:  Marije Oosting; Frank L van de Veerdonk; Thirumala-Devi Kanneganti; Patrick Sturm; Ineke Verschueren; Anneleen Berende; Jos W M van der Meer; Bart-Jan Kullberg; Mihai G Netea; Leo A B Joosten
Journal:  Eur J Immunol       Date:  2010-12-09       Impact factor: 5.532

5.  Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in alphabeta T-cell receptor transgenic mice.

Authors:  C Infante-Duarte; T Kamradt
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

6.  Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.

Authors:  Emily S Hansen; Velinka Medić; Joseph Kuo; Thomas F Warner; Ronald F Schell; Dean T Nardelli
Journal:  Infect Immun       Date:  2013-09-16       Impact factor: 3.441

7.  Involvement of CD4+ T lymphocytes in induction of severe destructive Lyme arthritis in inbred LSH hamsters.

Authors:  L C Lim; D M England; N J Glowacki; B K DuChateau; R F Schell
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

8.  Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells.

Authors:  A Vyakarnam; P M Matear; S J Martin; M Wagstaff
Journal:  Immunology       Date:  1995-09       Impact factor: 7.397

9.  CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract.

Authors:  M King; H Poya; J Rao; S Natarajan; A W Butch; N Aziz; S Kok; M H Chang; J M Lyons; K Ault; K A Kelly
Journal:  Drugs Today (Barc)       Date:  2009-11       Impact factor: 2.245

10.  HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis.

Authors:  Bettina Panagiota Iliopoulou; Mireia Guerau-de-Arellano; Brigitte T Huber
Journal:  Arthritis Rheum       Date:  2009-12
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