Literature DB >> 2237407

Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.

E Fikrig1, S W Barthold, F S Kantor, R A Flavell.   

Abstract

Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi. The gene for outer surface protein A (OspA) from B. burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli. C3H/HeJ mice actively immunized with live transformed E. coli or purified recombinant OspA protein produced antibodies to OspA and were protected from challenge with several strains of B. burgdorferi. Recombinant OspA is a candidate for a vaccine for Lyme borreliosis.

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Year:  1990        PMID： 2237407     DOI： 10.1126/science.2237407

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  210 in total

1.  In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies.

Authors:  A G Barbour; V Bundoc
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

Review 2.  Spirochaetal lipoproteins and pathogenesis.

Authors:  D A Haake
Journal:  Microbiology       Date:  2000-07       Impact factor: 2.777

3.  Immunogenicity of Borrelia burgdorferi arthritis-related protein.

Authors:  Sunlian Feng; Emir Hodzic; Kimberly Freet; Stephen W Barthold
Journal:  Infect Immun       Date:  2003-12       Impact factor: 3.441

4.  Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes.

Authors:  R R Montgomery; S E Malawista
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

5.  Differential immune responses to Borrelia burgdorferi in European wild rodent species influence spirochete transmission to Ixodes ricinus L. (Acari: Ixodidae).

Authors:  K Kurtenbach; A Dizij; H M Seitz; G Margos; S E Moter; M D Kramer; R Wallich; U E Schaible; M M Simon
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

6.  Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

Authors:  E Fikrig; H Tao; F S Kantor; S W Barthold; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection.

Authors:  B P Fung; G L McHugh; J M Leong; A C Steere
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

8.  Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A.

Authors:  W T Golde; K J Kappel; G Dequesne; C Feron; D Plainchamp; C Capiau; Y Lobet
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

9.  A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease.

Authors:  S Feng; S Das; T Lam; R A Flavell; E Fikrig
Journal:  Infect Immun       Date:  1995-09       Impact factor: 3.441

10.  Recombinant OspA protects dogs against infection and disease caused by Borrelia burgdorferi.

Authors:  Y F Chang; M J Appel; R H Jacobson; S J Shin; P Harpending; R Straubinger; L A Patrican; H Mohammed; B A Summers
Journal:  Infect Immun       Date:  1995-09       Impact factor: 3.441
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