| Literature DB >> 18308057 |
Richard M Sharpe1, Niels E Skakkebaek.
Abstract
Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders.Entities:
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Year: 2008 PMID： 18308057 DOI： 10.1016/j.fertnstert.2007.12.026
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329