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Literature DB >> 18297679

Antimalarial drugs - what is in use and what is in the pipeline.

Abstract

Malaria continues to be a potentially fatal threat to almost half of the world's population. In light of this threat, the armory to fight this disease is rather limited. Resistance against the most common and affordable antimalarials is widespread. Only few new drugs are in clinical development, most of them belong to long used classes of antimalarial drugs. This review will concisely cover the drugs which are currently in use, and describe the drug candidates which are in clinical evaluation.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18297679 DOI： 10.1002/ardp.200700184

Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751

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Cited

31 in total

1. Validation of ELISA for quantitation of artemisinin-based antimalarial drugs.

Authors: Min Wang; Yongliang Cui; Guofa Zhou; Guiyun Yan; Liwang Cui; Baomin Wang
Journal: Am J Trop Med Hyg Date: 2013-09-30 Impact factor: 2.345

2. Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Authors: Janina Preuss; Patrick Maloney; Satyamaheshwar Peddibhotla; Michael P Hedrick; Paul Hershberger; Palak Gosalia; Monika Milewski; Yujie Linda Li; Eliot Sugarman; Becky Hood; Eigo Suyama; Kevin Nguyen; Stefan Vasile; Eduard Sergienko; Arianna Mangravita-Novo; Michael Vicchiarelli; Danielle McAnally; Layton H Smith; Gregory P Roth; Jena Diwan; Thomas D Y Chung; Esther Jortzik; Stefan Rahlfs; Katja Becker; Anthony B Pinkerton; Lars Bode
Journal: J Med Chem Date: 2012-08-06 Impact factor: 7.446

Review 3. Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination.

Authors: Rashad Abdul-Ghani; John C Beier
Journal: Parasitol Res Date: 2014-09-04 Impact factor: 2.289

4. Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening.

Authors: Brian T Grimberg; Kerry O Grimberg
Journal: Expert Rev Anti Infect Ther Date: 2016-08-22 Impact factor: 5.091

5. Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.

Authors: Daniel Kiboi; Beatrice Irungu; Jennifer Orwa; Luna Kamau; Lynette Isabella Ochola-Oyier; Joseph Ngángá; Alexis Nzila
Journal: Exp Parasitol Date: 2014-10-18 Impact factor: 2.011

6. Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.

Authors: Eva Maria Novoa; Noelia Camacho; Anna Tor; Barrie Wilkinson; Steven Moss; Patricia Marín-García; Isabel G Azcárate; José M Bautista; Adam C Mirando; Christopher S Francklyn; Sònia Varon; Miriam Royo; Alfred Cortés; Lluís Ribas de Pouplana
Journal: Proc Natl Acad Sci U S A Date: 2014-12-08 Impact factor: 11.205

Antimalarial drugs - what is in use and what is in the pipeline.

1. Validation of ELISA for quantitation of artemisinin-based antimalarial drugs.

2. Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Review 3. Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination.

4. Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening.

5. Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.

6. Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.

Review 7. Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy.

8. Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.

9. Biological assay of a novel quinoxalinone with antimalarial efficacy on Plasmodium yoelii yoelii.

10. Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.