OBJECTIVE: To describe the use of botulinum toxin type A (BTX-A) in radiation fibrosis syndrome (RFS). DESIGN: Retrospective case series. SETTING: A large tertiary care cancer center. PARTICIPANTS: Twenty-three consecutive patients treated for sequelae of RFS with BTX-A. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: A description of the components of RFS thought to benefit from BTX-A injections and the patient's self-report of benefit from those injections. RESULTS: The sequelae of RFS for which BTX-A injection was thought to be indicated include radiation-induced cervical dystonia in 18 (78%), trigeminal nerve or cervical plexus neuralgia in 10 (43%), trismus in 7 (30%), migraine in 3 (13%), and thoracic pain in 1 (4%) patient. Most (87%) patients self-reported benefit from the injections. CONCLUSIONS: Initial clinical experience with the use of BTX-A as adjunctive treatment for select neuromuscular and musculoskeletal complications of RFS in a variety of cancer patients has been encouraging. Well-designed prospective studies are needed to clarify the potential beneficial role of BTX-A in specific sequelae of RFS.
OBJECTIVE: To describe the use of botulinum toxin type A (BTX-A) in radiation fibrosis syndrome (RFS). DESIGN: Retrospective case series. SETTING: A large tertiary care cancer center. PARTICIPANTS: Twenty-three consecutive patients treated for sequelae of RFS with BTX-A. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: A description of the components of RFS thought to benefit from BTX-A injections and the patient's self-report of benefit from those injections. RESULTS: The sequelae of RFS for which BTX-A injection was thought to be indicated include radiation-induced cervical dystonia in 18 (78%), trigeminal nerve or cervical plexus neuralgia in 10 (43%), trismus in 7 (30%), migraine in 3 (13%), and thoracic pain in 1 (4%) patient. Most (87%) patients self-reported benefit from the injections. CONCLUSIONS: Initial clinical experience with the use of BTX-A as adjunctive treatment for select neuromuscular and musculoskeletal complications of RFS in a variety of cancerpatients has been encouraging. Well-designed prospective studies are needed to clarify the potential beneficial role of BTX-A in specific sequelae of RFS.
Authors: Randy S Roth; Ji Qi; Jennifer B Hamill; Hyungjin M Kim; Tiffany N S Ballard; Andrea L Pusic; Edwin G Wilkins Journal: Breast Date: 2017-11-13 Impact factor: 4.380
Authors: Mimi R Borrelli; Nestor M Diaz Deleon; Sandeep Adem; Ronak A Patel; Shamik Mascharak; Abra H Shen; Dre Irizarry; Dung Nguyen; Arash Momeni; Michael T Longaker; Derrick C Wan Journal: Stem Cells Date: 2019-12-03 Impact factor: 6.277