| Literature DB >> 18291314 |
Christopher S Neumann1, Danica Galonić Fujimori, Christopher T Walsh.
Abstract
Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.Entities:
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Year: 2008 PMID： 18291314 DOI： 10.1016/j.chembiol.2008.01.006
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521