Literature DB >> 23226922

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids.

Shuanhu Gao1, Qiaoling Wang, Gelin Wang, Brett Lomenick, Jie Liu, Chih-Wei Fan, Lih-Wen Deng, Jing Huang, Lawrence Lum, Chuo Chen.   

Abstract

Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

Entities:  

Year:  2012        PMID： 23226922      PMCID： PMC3515072          DOI： 10.1055/s-0031-1290460

Source DB:  PubMed          Journal:  Synlett        ISSN： 0936-5214            Impact factor:   2.454


  79 in total

1.  Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology.

Authors:  Alan X. Xiang; Donald A. Watson; Taotao Ling; Emmanuel A. Theodorakis
Journal:  J Org Chem       Date:  1998-10-02       Impact factor: 4.354

2.  Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.

Authors:  Shunji Aoki; Yasuo Watanabe; Mami Sanagawa; Andi Setiawan; Naoyuki Kotoku; Motomasa Kobayashi
Journal:  J Am Chem Soc       Date:  2006-03-15       Impact factor: 15.419

3.  Target identification using drug affinity responsive target stability (DARTS).

Authors:  Brett Lomenick; Gwanghyun Jung; James A Wohlschlegel; Jing Huang
Journal:  Curr Protoc Chem Biol       Date:  2011-12-01

Review 4.  Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Authors:  Suzie J Scales; Frederic J de Sauvage
Journal:  Trends Pharmacol Sci       Date:  2009-05-13       Impact factor: 14.819

5.  Polarizing the Nazarov cyclization: the impact of dienone substitution pattern on reactivity and selectivity.

Authors:  Wei He; Ildiko R Herrick; Tulay A Atesin; Patrick A Caruana; Colleen A Kellenberger; Alison J Frontier
Journal:  J Am Chem Soc       Date:  2008-01-23       Impact factor: 15.419

6.  Palladium-catalyzed carbonylation reactions of aryl halides and related compounds.

Authors:  Anne Brennführer; Helfried Neumann; Matthias Beller
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

7.  A total synthesis of estrone based on a novel cascade of radical cyclizations.

Authors:  Gerald Pattenden; Miguel A Gonzalez; Stuart McCulloch; Affo Walter; Steven J Woodhead
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-10       Impact factor: 11.205

8.  A paracrine requirement for hedgehog signalling in cancer.

Authors:  Robert L Yauch; Stephen E Gould; Suzie J Scales; Tracy Tang; Hua Tian; Christina P Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Kallop; Michelle Nannini-Pepe; Karen Kotkow; James C Marsters; Lee L Rubin; Frederic J de Sauvage
Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962

9.  The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

Authors:  J P Incardona; W Gaffield; R P Kapur; H Roelink
Journal:  Development       Date:  1998-09       Impact factor: 6.868

10.  Synthesis of (+)-cortistatin A.

Authors:  Ryan A Shenvi; Carlos A Guerrero; Jun Shi; Chuang-Chuang Li; Phil S Baran
Journal:  J Am Chem Soc       Date:  2008-05-14       Impact factor: 15.419
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  4 in total

1.  De Novo Synthesis of the DEF-Ring Stereotriad Core of the Veratrum Alkaloids.

Authors:  Matthew A Horwitz; Jacob G Robins; Jeffrey S Johnson
Journal:  J Org Chem       Date:  2020-04-30       Impact factor: 4.354

2.  Natural products as inspiration for the development of new synthetic methods.

Authors:  Zhiqiang Ma; Chuo Chen
Journal:  J Chin Chem Soc       Date:  2017-08-09       Impact factor: 1.967

3.  Drug affinity responsive target stability (DARTS) for small-molecule target identification.

Authors:  Melody Y Pai; Brett Lomenick; Heejun Hwang; Robert Schiestl; William McBride; Joseph A Loo; Jing Huang
Journal:  Methods Mol Biol       Date:  2015

4.  Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge, Terpios hoshinota.

Authors:  Yu-Hsiang Chen; Hsing-Ju Chen; Cheng-Yu Yang; Jia-Ho Shiu; Daphne Z Hoh; Pei-Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin-Han Shih; Szu-Hsien Lin; Chi-Ming Yang; James Davis Reimer; Euichi Hirose; Budhi Hascaryo Iskandar; Hui Huang; Peter J Schupp; Chun Hong James Tan; Hideyuki Yamashiro; Ming-Hui Liao; Sen-Lin Tang
Journal:  Environ Microbiol       Date:  2021-10-27       Impact factor: 5.476
  4 in total

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