Literature DB >> 18256475

Distribution of L-azetidine-2-carboxylate N-acetyltransferase in yeast.

Masaru Wada1, Kae Okabe, Michihiko Kataoka, Sakayu Shimizu, Atsushi Yokota, Hiroshi Takagi.   

Abstract

The budding yeast Saccharomyces cerevisiae Sigma1278b contains the MPR1 gene encoding N-acetyltransferase, which detoxifies the L-proline analog L-azetidine-2-carboxylate (AZC). Of 131 yeasts tested, AZC acetyltransferase activity was detected in 17 strains of 41 strains that showed AZC resistance. Degenerate-PCR analysis revealed that two strains, i.e., Candida saitoana AKU4533 and Wickerhamia fluorescens AKU4722, contained a DNA fragment highly homologous to MPR1. This indicates that AZC acetyltransferases are widely distributed in yeasts.

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Year:  2008        PMID： 18256475     DOI： 10.1271/bbb.70534

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  6 in total

1.  Heterologous expression of Saccharomyces cerevisiae MPR1 gene confers tolerance to ethanol and L: -azetidine-2-carboxylic acid in Hansenula polymorpha.

Authors:  Olena P Ishchuk; Charles A Abbas; Andriy A Sibirny
Journal:  J Ind Microbiol Biotechnol       Date:  2009-12-05       Impact factor: 3.346

2.  Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism.

Authors:  Ryo Nasuno; Yoshinori Hirano; Takafumi Itoh; Toshio Hakoshima; Takao Hibi; Hiroshi Takagi
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-01       Impact factor: 11.205

3.  Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast.

Authors:  Ryo Nasuno; Saeka Hirase; Saki Norifune; Daisuke Watanabe; Hiroshi Takagi
Journal:  J Biochem       Date:  2015-10-09       Impact factor: 3.387

4.  Crystallization and preliminary crystallographic analysis of N-acetyltransferase Mpr1 from Saccharomyces cerevisiae.

Authors:  Takao Hibi; Hiromi Yamamoto; Genichi Nakamura; Hiroshi Takagi
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-01-31

5.  Exomer complex regulates protein traffic at the TGN through differential interactions with cargos and clathrin adaptor complexes.

Authors:  Carlos Anton-Plagaro; Noelia Sanchez; Rosario Valle; Jose Miguel Mulet; Mara C Duncan; Cesar Roncero
Journal:  FASEB J       Date:  2021-06       Impact factor: 5.834

6.  A highly conserved mechanism for the detoxification and assimilation of the toxic phytoproduct L-azetidine-2-carboxylic acid in Aspergillus nidulans.

Authors:  Ada Biratsi; Alexandros Athanasopoulos; Vassili N Kouvelis; Christos Gournas; Vicky Sophianopoulou
Journal:  Sci Rep       Date:  2021-04-01       Impact factor: 4.379
  6 in total

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