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Literature DB >> 18250629

DNA torsional stress propagates through chromatin fiber and participates in transcriptional regulation.

Christophe Lavelle.

Abstract

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Year: 2008 PMID： 18250629 DOI： 10.1038/nsmb0208-123

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

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27 in total

1. Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.

Authors: Aziz El Hage; Sarah L French; Ann L Beyer; David Tollervey
Journal: Genes Dev Date: 2010-07-15 Impact factor: 11.361

2. Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.

Authors: Yong Qin; Jessica S Fortin; Denise Tye; Mary Gleason-Guzman; Tracy A Brooks; Laurence H Hurley
Journal: Biochemistry Date: 2010-05-18 Impact factor: 3.162

3. Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.

Authors: Sarah L French; Martha L Sikes; Robert D Hontz; Yvonne N Osheim; Tashima E Lambert; Aziz El Hage; Mitchell M Smith; David Tollervey; Jeffrey S Smith; Ann L Beyer
Journal: Mol Cell Biol Date: 2010-11-22 Impact factor: 4.272

DNA torsional stress propagates through chromatin fiber and participates in transcriptional regulation.

1. Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.

2. Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.

3. Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.

4. Twist propagation in dinucleosome arrays.

5. Allosteric modulation of DNA by small molecules.

6. Linker histones incorporation maintains chromatin fiber plasticity.

7. Mu transpososome and RecBCD nuclease collaborate in the repair of simple Mu insertions.

Review 8. Structural insights into G-quadruplexes: towards new anticancer drugs.

Review 9. The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.

10. Topological origins of chromosomal territories.