| Literature DB >> 18247570 |
John E Leet1, Xiaohong Liu, Dieter M Drexler, Joseph L Cantone, Stella Huang, Stephen W Mamber, Craig R Fairchild, Raouf Hussain, David J Newman, David G I Kingston.
Abstract
Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin-(3',5'-diol) ( 1) and psoroxanthin ( 4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line).Entities:
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Year: 2008 PMID： 18247570 PMCID： PMC2930019 DOI： 10.1021/np070523l
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050