| Literature DB >> 7189773 |
S M Kupchan, D R Streelman, A T Sneden.
Abstract
An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.Entities:
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Year: 1980 PMID： 7189773 DOI： 10.1021/np50008a010
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050