Literature DB >> 15317447

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

Aberra Fura1, Yue-Zhong Shu, Mingshe Zhu, Ronald L Hanson, Vikram Roongta, W Griffith Humphreys.   

Abstract

Mesh：

Substances：

Year:  2004        PMID： 15317447     DOI： 10.1021/jm040066v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  16 in total

1.  Intranasal delivery--modification of drug metabolism and brain disposition.

Authors:  Yin Cheong Wong; Zhong Zuo
Journal:  Pharm Res       Date:  2010-04-06       Impact factor: 4.200

2.  Characterization of the Impact of Drug Metabolism on the Gas-Phase Structures of Drugs Using Ion Mobility-Mass Spectrometry.

Authors:  Dylan H Ross; Ryan P Seguin; Libin Xu
Journal:  Anal Chem       Date:  2019-10-29       Impact factor: 6.986

Review 3.  Predicting drug metabolism: experiment and/or computation?

Authors:  Johannes Kirchmair; Andreas H Göller; Dieter Lang; Jens Kunze; Bernard Testa; Ian D Wilson; Robert C Glen; Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2015-04-24       Impact factor: 84.694

4.  Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

Authors:  Claudia Mugnaini; Stefania Nocerino; Valentina Pedani; Serena Pasquini; Andrea Tafi; Maria De Chiaro; Luca Bellucci; Massimo Valoti; Francesca Guida; Livio Luongo; Stefania Dragoni; Alessia Ligresti; Avraham Rosenberg; Daniele Bolognini; Maria Grazia Cascio; Roger G Pertwee; Ruin Moaddel; Sabatino Maione; Vincenzo Di Marzo; Federico Corelli
Journal:  ChemMedChem       Date:  2012-03-02       Impact factor: 3.466

5.  Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.

Authors:  Aiwen Li; Chester C Yuan; David Chow; Michelle Chen; Maurice G Emery; Clarence Hale; Xiping Zhang; Raju Subramanian; David J St Jean; Renee Komorowski; Murielle Véniant; Minghan Wang; Christopher Fotsch
Journal:  ACS Med Chem Lett       Date:  2011-09-13       Impact factor: 4.345

Review 6.  Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).

Authors:  Laura E Russell; Mary Alexandra Schleiff; Eric Gonzalez; Aaron G Bart; Fabio Broccatelli; Jessica H Hartman; W Griffith Humphreys; Volker M Lauschke; Iain Martin; Chukwunonso Nwabufo; Bhagwat Prasad; Emily E Scott; Matthew Segall; Ryan Takahashi; Mitchell E Taub; Jasleen K Sodhi
Journal:  Drug Metab Rev       Date:  2020-05-26       Impact factor: 4.518

7.  Projection of exposure and efficacious dose prior to first-in-human studies: how successful have we been?

Authors:  Christine Huang; Ming Zheng; Zheng Yang; A David Rodrigues; Punit Marathe
Journal:  Pharm Res       Date:  2007-09-25       Impact factor: 4.200

8.  Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Authors:  John E Leet; Xiaohong Liu; Dieter M Drexler; Joseph L Cantone; Stella Huang; Stephen W Mamber; Craig R Fairchild; Raouf Hussain; David J Newman; David G I Kingston
Journal:  J Nat Prod       Date:  2008-02-05       Impact factor: 4.050

9.  SAR of a new antischistosomal urea carboxylic acid.

Authors:  Jianbo Wu; Chunkai Wang; Cécile Häberli; Karen L White; David M Shackleford; Gong Chen; Yuxiang Dong; Susan A Charman; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2018-10-25       Impact factor: 2.823

10.  Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.

Authors:  Julie A Lemm; John E Leet; Donald R O'Boyle; Jeffrey L Romine; Xiaohua Stella Huang; Daniel R Schroeder; Jeffrey Alberts; Joseph L Cantone; Jin-Hua Sun; Peter T Nower; Scott W Martin; Michael H Serrano-Wu; Nicholas A Meanwell; Lawrence B Snyder; Min Gao
Journal:  Antimicrob Agents Chemother       Date:  2011-05-16       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.