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Literature DB >> 182422

Leucocyte capillary migration: an adherence dependent phenomenon.

Abstract

To determine the mode of action of leucocyte inhibitory factor (LIF) on polymorphonuclear leucocyte (PMN) migration out of capillary tubes, this phenomenon has been compared with PMN adhesion to cotton wool columns. Colchicine and vinblastine sulphate had no effect on either of these processes but cytochalasin B caused marked inhibition of PMN migration and increased PMN adhesion. The cytochalasin B effect could be reversed in the presence of drugs known to increase intracellular levels of cyclic AMP. For inhibition of PMN migration by LIF, Mg2+ but not Ca2+ was essential. LIF not only inhibited PMN migration but also increased PMN adhesion to cotton wool columns. LIF inhibitory activity on PMN migration was not affected by colchicine or vinblastine. Leucocyte migration and adhesion depend on similar mechanisms, and are both influenced by LIF which probably acts by affecting micro-filament function.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 182422 PMCID： PMC1541343

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

14 in total

Review 1. Chemotaxis and random mobility. Clinical and biologic differentiation.

Authors: M E Miller
Journal: Antibiot Chemother (1971) Date: 1974

Review 2. Mechanism of movement and maintenance of polarity in leucocytes.

Authors: A C Allison
Journal: Antibiot Chemother (1971) Date: 1974

3. The mechanism of action of soluble lymphocytic mediators. II. Modification of macrophage migration and migration inhibitory factor action by drugs, enzymes and cationic environment.

Authors: E Pick; S Manheimer
Journal: Cell Immunol Date: 1974-03-30 Impact factor: 4.868

4. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

Authors: R R MacGregor; P J Spagnuolo; A L Lentnek
Journal: N Engl J Med Date: 1974-09-26 Impact factor: 91.245

5. Microtubule formation in vitro in solutions containing low calcium concentrations.

Authors: R C Weisenberg
Journal: Science Date: 1972-09-22 Impact factor: 47.728

6. Membrane dynamics in the action of dibutyryl adenosine 3':5'-cyclic monophosphate and testosterone on mammalian cells.

Authors: T T Puck; C A Waldren; A W Hsie
Journal: Proc Natl Acad Sci U S A Date: 1972-07 Impact factor: 11.205

7. The regulatory role of divalent cations in human granulocyte chemotaxis. Evidence for an association between calcium exchanges and microtubule assembly.

Authors: J I Gallin; A S Rosenthal
Journal: J Cell Biol Date: 1974-09 Impact factor: 10.539

8. The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration.

Authors: R Lomnitzer; A R Rabson; H J Koornhof
Journal: Clin Exp Immunol Date: 1976-04 Impact factor: 4.330

Leucocyte capillary migration: an adherence dependent phenomenon.

Review 1. Chemotaxis and random mobility. Clinical and biologic differentiation.

Review 2. Mechanism of movement and maintenance of polarity in leucocytes.

3. The mechanism of action of soluble lymphocytic mediators. II. Modification of macrophage migration and migration inhibitory factor action by drugs, enzymes and cationic environment.

4. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

5. Microtubule formation in vitro in solutions containing low calcium concentrations.

6. Membrane dynamics in the action of dibutyryl adenosine 3':5'-cyclic monophosphate and testosterone on mammalian cells.

7. The regulatory role of divalent cations in human granulocyte chemotaxis. Evidence for an association between calcium exchanges and microtubule assembly.

8. The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration.

9. Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF).

10. Colchicine binding in tissue slices. Decrease by calcium and biphasic effect of adenosine-3', 5'-monophosphate.

1. Microtubule asymmetry during neutrophil polarization and migration.

2. Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.

3. Lymphokine-induced neutrophil aggregation.

4. The effect of PHA-activated MN-cell supernatants on polymorphonuclear leucocyte function.

5. Inhibitory effect of prostaglandin A1 on neutrophil motility.

6. Defective neutrophil motility and recurrent infection. In vitro and in vivo effects of levamisole.