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Literature DB >> 216508

Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.

Abstract

Polymorph migration stimulator (PMS) is a peptide factor produced by an in vitro reaction between glucocorticoids and human mononuclear phagocytes. This study was undertaken to determine the significance of the stimulatory effect of PMS on the capillary tube migration of human polymorphs. Colchicine, vinblastine and Nocodazole, all of which inhibit microtubular assembly, are shown to stimulate migration. Conversely, deuterium oxide which stabilizes microtubules inhibits migration. Increased intracellular cyclic AMP is associated with microtubular inhibition and isoprenaline, theophylline and dibutyryl cyclic AMP are also found to stimulate capillary tube migration. These results suggest that PMS acts by inhibiting the assembly of polymorph microtubules, an effect which may be mediated by cyclic AMP in the same manner as other peptide hormones.

Entities: Chemical Species

Mesh：

Substances：

Year: 1978 PMID： 216508 PMCID： PMC1537436

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

32 in total

1. Studies on the physico-chemical characteristics of polymorph migration stimulator.

Authors: R D Stevenson; A C Gray
Journal: Clin Exp Immunol Date: 1976-12 Impact factor: 4.330

2. Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.

Authors: F MURAD; Y M CHI; T W RALL; E W SUTHERLAND
Journal: J Biol Chem Date: 1962-04 Impact factor: 5.157

3. Cyclic AMP affects macrophage migration.

Authors: E Pick
Journal: Nat New Biol Date: 1972-08-09

4. Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.

Authors: R L Tse; P Phelps; D Urban
Journal: J Lab Clin Med Date: 1972-08

5. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

Authors: R R MacGregor; P J Spagnuolo; A L Lentnek
Journal: N Engl J Med Date: 1974-09-26 Impact factor: 91.245

6. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

Authors: R W BUTCHER; E W SUTHERLAND
Journal: J Biol Chem Date: 1962-04 Impact factor: 5.157

7. Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis.

Authors: T P Stossel; R J Mason; J Hartwig; M Vaughan
Journal: J Clin Invest Date: 1972-03 Impact factor: 14.808

8. Subplasmalemmal microfilaments and microtubules in resting and phagocytizing cultivated macrophages.

Authors: E P Reaven; S G Axline
Journal: J Cell Biol Date: 1973-10 Impact factor: 10.539

9. Studies on the pathogenesis of acute inflammation. II. The action of cortisone on the inflammatory response to thermal injury.

Authors: F ALLISON; M R SMITH; W B WOOD
Journal: J Exp Med Date: 1955-12-01 Impact factor: 14.307

10. The aggregation of rabbit polymorphonuclear leucocytes: effects of antimitotic agents, cyclic nucleotides and methyl xanthines.

Authors: J M Lackie
Journal: J Cell Sci Date: 1974-10 Impact factor: 5.285

5 in total

Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.

1. Studies on the physico-chemical characteristics of polymorph migration stimulator.

2. Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.

3. Cyclic AMP affects macrophage migration.

4. Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.

5. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

6. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

7. Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis.

8. Subplasmalemmal microfilaments and microtubules in resting and phagocytizing cultivated macrophages.

9. Studies on the pathogenesis of acute inflammation. II. The action of cortisone on the inflammatory response to thermal injury.

10. The aggregation of rabbit polymorphonuclear leucocytes: effects of antimitotic agents, cyclic nucleotides and methyl xanthines.

1. Microtubule asymmetry during neutrophil polarization and migration.

2. The effects of anesthesia and surgery on count and function of neutrophils.

3. Effect of estradiol and progesterone on lymphocyte and neutrophil functions in steers.

4. Effects of in vivo dexamethasone administration on in vitro bovine polymorphonuclear leukocyte function.

5. A factor released by monocytes in the presence of dexamethasone stimulates neutrophil locomotion.