| Literature DB >> 18226902 |
Chunhui Zhou1, Jaeki Min, Zhigang Liu, Anne Young, Heather Deshazer, Tian Gao, Young-Tae Chang, Neville R Kallenbach.
Abstract
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.Entities:
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Year: 2008 PMID： 18226902 DOI： 10.1016/j.bmcl.2008.01.031
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823