Literature DB >> 18224409

Chromatin regulation by AML1 complex.

Hitoshi Yoshida1, Issay Kitabayashi.   

Abstract

The AML1 gene is the most frequent target of chromosomal translocations in acute leukemias. AML1 is essential for definitive hematopoiesis and regulates transcription of its target genes by binding to the specific DNA sequence. AML1 forms large multiprotein complexes including CBFbeta as a "core component" as well as several classes of chromatin modulators such as p300/CBP, MOZ, PML and HIPK2 as "regulatory complex". In this review, we describe the mechanisms by which AML1 complex regulates gene transcription and hematopoiesis, and its disruption by the leukemia-associated chromosomal translocations that affect genes for components of AML1 complex in view of deregulation of chromatin structure.

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Year:  2007        PMID： 18224409     DOI： 10.1007/s12185-007-0004-0

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  36 in total

1.  Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

Authors:  H Chen; R J Lin; W Xie; D Wilpitz; R M Evans
Journal:  Cell       Date:  1999-09-03       Impact factor: 41.582

2.  Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

Authors:  Yukiko Aikawa; Lan Anh Nguyen; Kyoichi Isono; Nobuyuki Takakura; Yusuke Tagata; M Lienhard Schmitz; Haruhiko Koseki; Issay Kitabayashi
Journal:  EMBO J       Date:  2006-08-17       Impact factor: 11.598

3.  Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

Authors:  K Sasaki; H Yagi; R T Bronson; K Tominaga; T Matsunashi; K Deguchi; Y Tani; T Kishimoto; T Komori
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 4.  Chromatin modifying activity of leukaemia associated fusion proteins.

Authors:  Luciano Di Croce
Journal:  Hum Mol Genet       Date:  2005-04-15       Impact factor: 6.150

5.  Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

Authors:  Shujun Liu; Tiansheng Shen; Lenguyen Huynh; Marko I Klisovic; Laura J Rush; Jamie L Ford; Jianhua Yu; Brian Becknell; Yu Li; Chunhui Liu; Tamara Vukosavljevic; Susan P Whitman; Kun-Sang Chang; John C Byrd; Danilo Perrotti; Christoph Plass; Guido Marcucci
Journal:  Cancer Res       Date:  2005-02-15       Impact factor: 12.701

6.  Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor.

Authors:  M Niki; H Okada; H Takano; J Kuno; K Tani; H Hibino; S Asano; Y Ito; M Satake; T Noda
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-27       Impact factor: 11.205

7.  Epigenetic consequences of AML1-ETO action at the human c-FMS locus.

Authors:  George A Follows; Hiromi Tagoh; Pascal Lefevre; Donald Hodge; Gareth J Morgan; Constanze Bonifer
Journal:  EMBO J       Date:  2003-06-02       Impact factor: 11.598

8.  AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

Authors:  Motoshi Ichikawa; Takashi Asai; Toshiki Saito; Sachiko Seo; Ieharu Yamazaki; Tetsuya Yamagata; Kinuko Mitani; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa; Hisamaru Hirai
Journal:  Nat Med       Date:  2004-02-15       Impact factor: 53.440

9.  AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Authors:  T Okuda; J van Deursen; S W Hiebert; G Grosveld; J R Downing
Journal:  Cell       Date:  1996-01-26       Impact factor: 41.582

10.  The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

Authors:  S P Romana; M Mauchauffé; M Le Coniat; I Chumakov; D Le Paslier; R Berger; O A Bernard
Journal:  Blood       Date:  1995-06-15       Impact factor: 22.113
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  11 in total

1.  The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Authors:  Gang Huang; Xinghui Zhao; Lan Wang; Shannon Elf; Hao Xu; Xinyang Zhao; Goro Sashida; Yue Zhang; Yan Liu; Jennifer Lee; Silvia Menendez; Youyang Yang; Xiaomei Yan; Pu Zhang; Daniel G Tenen; Motomi Osato; James J-D Hsieh; Stephen D Nimer
Journal:  Blood       Date:  2011-10-19       Impact factor: 22.113

2.  Fadd and Skp2 are possible downstream targets of RUNX1-EVI1.

Authors:  Kazuhiro Maki; Fusako Sugita; Yuka Nakamura; Ko Sasaki; Kinuko Mitani
Journal:  Int J Hematol       Date:  2012-12-19       Impact factor: 2.490

3.  Tyrosyl phosphorylation toggles a Runx1 switch.

Authors:  Benjamin G Neel; Nancy A Speck
Journal:  Genes Dev       Date:  2012-07-15       Impact factor: 11.361

4.  Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.

Authors:  Ditsa Levanon; Varda Negreanu; Joseph Lotem; Karen Rae Bone; Ori Brenner; Dena Leshkowitz; Yoram Groner
Journal:  Mol Cell Biol       Date:  2014-01-13       Impact factor: 4.272

5.  MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms.

Authors:  Hannah M Heair; Austin G Kemper; Bhaskar Roy; Helena B Lopes; Harunur Rashid; John C Clarke; Lubana K Afreen; Emanuela P Ferraz; Eddy Kim; Amjad Javed; Marcio M Beloti; Mary MacDougall; Mohammad Q Hassan
Journal:  Mol Cell Biol       Date:  2015-06-29       Impact factor: 4.272

Review 6.  Post-translational modifications of Runx1 regulate its activity in the cell.

Authors:  Lan Wang; Gang Huang; Xinyang Zhao; Megan A Hatlen; Ly Vu; Fan Liu; Stephen D Nimer
Journal:  Blood Cells Mol Dis       Date:  2009-04-21       Impact factor: 3.039

Review 7.  The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Authors:  Flor M Perez-Campo; Guilherme Costa; Michael Lie-a-Ling; Valerie Kouskoff; Georges Lacaud
Journal:  Immunology       Date:  2013-06       Impact factor: 7.397

8.  Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.

Authors:  Farzin Pourfarzad; Marieke von Lindern; Azita Azarkeivan; Jun Hou; Sima Kheradmand Kia; Fatemehsadat Esteghamat; Wilfred van Ijcken; Sjaak Philipsen; Hossein Najmabadi; Frank Grosveld
Journal:  Haematologica       Date:  2012-10-25       Impact factor: 9.941

Review 9.  RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia.

Authors:  Emiel van der Kouwe; Philipp Bernhard Staber
Journal:  Int J Mol Sci       Date:  2019-01-16       Impact factor: 5.923

10.  KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer.

Authors:  Brittany Turner-Ivey; Stephen T Guest; Jonathan C Irish; Christiana S Kappler; Elizabeth Garrett-Mayer; Robert C Wilson; Stephen P Ethier
Journal:  Neoplasia       Date:  2014-08       Impact factor: 5.715
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