Literature DB >> 19386523

Post-translational modifications of Runx1 regulate its activity in the cell.

Lan Wang1, Gang Huang, Xinyang Zhao, Megan A Hatlen, Ly Vu, Fan Liu, Stephen D Nimer.   

Abstract

In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

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Year:  2009        PMID： 19386523      PMCID： PMC2743917          DOI： 10.1016/j.bcmd.2009.03.005

Source DB:  PubMed          Journal:  Blood Cells Mol Dis        ISSN： 1079-9796            Impact factor:   3.039


  59 in total

1.  Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

Authors:  Woojin An; Jaehoon Kim; Robert G Roeder
Journal:  Cell       Date:  2004-06-11       Impact factor: 41.582

Review 2.  ETO interacting proteins.

Authors:  Bruce A Hug; Mitchell A Lazar
Journal:  Oncogene       Date:  2004-05-24       Impact factor: 9.867

Review 3.  CpG-rich islands and the function of DNA methylation.

Authors:  A P Bird
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

4.  The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.

Authors:  T Tanaka; M Kurokawa; K Ueki; K Tanaka; Y Imai; K Mitani; K Okazaki; N Sagata; Y Yazaki; Y Shibata; T Kadowaki; H Hirai
Journal:  Mol Cell Biol       Date:  1996-07       Impact factor: 4.272

5.  The AML1/ETO fusion protein activates transcription of BCL-2.

Authors:  L Klampfer; J Zhang; A O Zelenetz; H Uchida; S D Nimer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

6.  Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins.

Authors:  Anja Moldenhauer; Richard C Frank; Javier Pinilla-Ibarz; Gudrun Holland; Piernicola Boccuni; David A Scheinberg; Abdulgabar Salama; Karl Seeger; Malcolm A S Moore; Stephen D Nimer
Journal:  J Leukoc Biol       Date:  2004-06-14       Impact factor: 4.962

7.  The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

Authors:  R Frank; J Zhang; H Uchida; S Meyers; S W Hiebert; S D Nimer
Journal:  Oncogene       Date:  1995-12-21       Impact factor: 9.867

8.  AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

Authors:  Motoshi Ichikawa; Takashi Asai; Toshiki Saito; Sachiko Seo; Ieharu Yamazaki; Tetsuya Yamagata; Kinuko Mitani; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa; Hisamaru Hirai
Journal:  Nat Med       Date:  2004-02-15       Impact factor: 53.440

9.  AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.

Authors:  Florence Bernardin-Fried; Tanawan Kummalue; Suzanne Leijen; Michael I Collector; Katya Ravid; Alan D Friedman
Journal:  J Biol Chem       Date:  2004-01-27       Impact factor: 5.157

Review 10.  Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells.

Authors:  Stephen D Nimer; Malcolm A S Moore
Journal:  Oncogene       Date:  2004-05-24       Impact factor: 9.867
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  15 in total

1.  The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Authors:  Gang Huang; Xinghui Zhao; Lan Wang; Shannon Elf; Hao Xu; Xinyang Zhao; Goro Sashida; Yue Zhang; Yan Liu; Jennifer Lee; Silvia Menendez; Youyang Yang; Xiaomei Yan; Pu Zhang; Daniel G Tenen; Motomi Osato; James J-D Hsieh; Stephen D Nimer
Journal:  Blood       Date:  2011-10-19       Impact factor: 22.113

Review 2.  AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.

Authors:  Megan A Hatlen; Lan Wang; Stephen D Nimer
Journal:  Front Med       Date:  2012-08-09       Impact factor: 4.592

Review 3.  Posttranslational modifications of RUNX1 as potential anticancer targets.

Authors:  S Goyama; G Huang; M Kurokawa; J C Mulloy
Journal:  Oncogene       Date:  2014-09-29       Impact factor: 9.867

4.  Tyrosyl phosphorylation toggles a Runx1 switch.

Authors:  Benjamin G Neel; Nancy A Speck
Journal:  Genes Dev       Date:  2012-07-15       Impact factor: 11.361

5.  PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.

Authors:  Ly P Vu; Fabiana Perna; Lan Wang; Francesca Voza; Maria E Figueroa; Paul Tempst; Hediye Erdjument-Bromage; Rui Gao; Sisi Chen; Elisabeth Paietta; Tony Deblasio; Ari Melnick; Yan Liu; Xinyang Zhao; Stephen D Nimer
Journal:  Cell Rep       Date:  2013-12-12       Impact factor: 9.423

6.  The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.

Authors:  Lan Wang; Alexander Gural; Xiao-Jian Sun; Xinyang Zhao; Fabiana Perna; Gang Huang; Megan A Hatlen; Ly Vu; Fan Liu; Haiming Xu; Takashi Asai; Hao Xu; Tony Deblasio; Silvia Menendez; Francesca Voza; Yanwen Jiang; Philip A Cole; Jinsong Zhang; Ari Melnick; Robert G Roeder; Stephen D Nimer
Journal:  Science       Date:  2011-07-14       Impact factor: 47.728

7.  Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

Authors:  Shinsuke Mizutani; Tatsushi Yoshida; Xinyang Zhao; Stephen D Nimer; Masafumi Taniwaki; Tsukasa Okuda
Journal:  Br J Haematol       Date:  2015-05-26       Impact factor: 6.998

8.  RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.

Authors:  Olga N Kuvardina; Julia Herglotz; Stephan Kolodziej; Nicole Kohrs; Stefanie Herkt; Bartosch Wojcik; Thomas Oellerich; Jasmin Corso; Kira Behrens; Ashok Kumar; Helge Hussong; Henning Urlaub; Joachim Koch; Hubert Serve; Halvard Bonig; Carol Stocking; Michael A Rieger; Jörn Lausen
Journal:  Blood       Date:  2015-04-24       Impact factor: 22.113

Review 9.  RUNX1: A microRNA hub in normal and malignant hematopoiesis.

Authors:  Stefano Rossetti; Nicoletta Sacchi
Journal:  Int J Mol Sci       Date:  2013-01-14       Impact factor: 5.923

10.  Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia.

Authors:  Limin Zou; Han Zhang; Chaohao Du; Xiao Liu; Shanshan Zhu; Wei Zhang; Zhigang Li; Chao Gao; Xiaoxi Zhao; Mei Mei; Shilai Bao; Huyong Zheng
Journal:  J Hematol Oncol       Date:  2012-07-27       Impact factor: 17.388
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