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Literature DB >> 22802526

Tyrosyl phosphorylation toggles a Runx1 switch.

Abstract

The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587-1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.

Entities: Chemical Gene

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Year: 2012 PMID： 22802526 PMCID： PMC3404380 DOI： 10.1101/gad.198051.112

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

57 in total

1. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).

Authors: T L Gu; T L Goetz; B J Graves; N A Speck
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

2. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

Authors: Yukiko Aikawa; Lan Anh Nguyen; Kyoichi Isono; Nobuyuki Takakura; Yusuke Tagata; M Lienhard Schmitz; Haruhiko Koseki; Issay Kitabayashi
Journal: EMBO J Date: 2006-08-17 Impact factor: 11.598

3. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Authors: Gordon Chan; Demetrios Kalaitzidis; Tatiana Usenko; Jeffery L Kutok; Wentian Yang; M Golam Mohi; Benjamin G Neel
Journal: Blood Date: 2009-01-29 Impact factor: 22.113

Review 4. Multiple copies of RUNX1: description of 14 new patients, follow-up, and a review of the literature.

Authors: Patricia Pérez-Vera; Oreth Montero-Ruíz; Sara Frías; Roberto Rivera-Luna; Adán Valladares; Diego Arenas; Rogelio Paredes-Aguilera; Alessandra Carnevale
Journal: Cancer Genet Cytogenet Date: 2008-01-15

5. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells.

Authors: Fuping Zhang; Guangxun Meng; Warren Strober
Journal: Nat Immunol Date: 2008-10-12 Impact factor: 25.606

6. Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.

Authors: Hui Huang; Ming Yu; Thomas E Akie; Tyler B Moran; Andrew J Woo; Nathan Tu; Zachary Waldon; Yin Yin Lin; Hanno Steen; Alan B Cantor
Journal: Mol Cell Biol Date: 2009-05-26 Impact factor: 4.272

7. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

Authors: Motoshi Ichikawa; Takashi Asai; Toshiki Saito; Sachiko Seo; Ieharu Yamazaki; Tetsuya Yamagata; Kinuko Mitani; Shigeru Chiba; Seishi Ogawa; Mineo Kurokawa; Hisamaru Hirai
Journal: Nat Med Date: 2004-02-15 Impact factor: 53.440

2. Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes.

Authors: Seung-Young Choi; Sung-Kyun Park; Han-Woong Yoo; Joo-Hyun Pi; Chang-Joong Kang
Journal: J Biol Chem Date: 2016-05-19 Impact factor: 5.157

2 in total

Tyrosyl phosphorylation toggles a Runx1 switch.

1. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).

2. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

3. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Review 4. Multiple copies of RUNX1: description of 14 new patients, follow-up, and a review of the literature.

5. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells.

6. Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.

7. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.

Review 8. RUNX proteins in transcription factor networks that regulate T-cell lineage choice.

9. Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.

10. Molecular targets for the treatment of juvenile myelomonocytic leukemia.

Review 1. Posttranslational modifications of RUNX1 as potential anticancer targets.

2. Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes.