Literature DB >> 18221872

Synthesis and anticancer activity studies of cyclopamine derivatives.

Jianjun Zhang1, Massoud Garrossian, Dale Gardner, Arash Garrossian, Young-Tae Chang, Yun Kyung Kim, Cheng-Wei Tom Chang.   

Abstract

A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine.

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Year:  2008        PMID： 18221872     DOI： 10.1016/j.bmcl.2008.01.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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