Literature DB >> 22401662

A piperidine chiron for the Veratrum alkaloids.

Douglass F Taber1, Peter W DeMatteo.   

Abstract

A Veratrum piperidine chiron was prepared over 11 steps (7.9% yield) from (-)-citronellal. Three methods for the installation of the propargylic side chain onto a cyclic enamide are presented.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 22401662      PMCID: PMC4226469          DOI: 10.1021/jo2026228

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  40 in total

Review 1.  The Hedgehog and Wnt signalling pathways in cancer.

Authors:  J Taipale; P A Beachy
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

2.  The veratrine alkaloids; the alkaloids of Veratrum viride.

Authors:  W A JACOBS; L C CRAIG
Journal:  J Biol Chem       Date:  1945       Impact factor: 5.157

3.  Ozonolysis in solvent/water mixtures: direct conversion of alkenes to aldehydes and ketones.

Authors:  Charles E Schiaffo; Patrick H Dussault
Journal:  J Org Chem       Date:  2008-05-28       Impact factor: 4.354

4.  Following the hedgehog to new cancer therapies.

Authors:  Andrzej A Dlugosz; Moshe Talpaz
Journal:  N Engl J Med       Date:  2009-09-02       Impact factor: 91.245

5.  Stereoselective synthesis of C5-C20 and C21-C34 subunits of the core structure of the aplyronines. Applications of enantioselective additions of chiral allenylindium reagents to chiral aldehydes.

Authors:  J A Marshall; B A Johns
Journal:  J Org Chem       Date:  2000-03-10       Impact factor: 4.354

6.  Stereoselective synthesis of 2,5,6-trisubstituted piperidines.

Authors:  Joel M Harris; Albert Padwa
Journal:  Org Lett       Date:  2002-06-13       Impact factor: 6.005

Review 7.  Hedgehog beyond medulloblastoma and basal cell carcinoma.

Authors:  Stephan Teglund; Rune Toftgård
Journal:  Biochim Biophys Acta       Date:  2010-01-18

Review 8.  Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Authors:  Suzie J Scales; Frederic J de Sauvage
Journal:  Trends Pharmacol Sci       Date:  2009-05-13       Impact factor: 14.819

9.  A paracrine requirement for hedgehog signalling in cancer.

Authors:  Robert L Yauch; Stephen E Gould; Suzie J Scales; Tracy Tang; Hua Tian; Christina P Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Kallop; Michelle Nannini-Pepe; Karen Kotkow; James C Marsters; Lee L Rubin; Frederic J de Sauvage
Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962

10.  Synthesis and antimalarial activities of 12 beta-allyldeoxoartemisinin and its derivatives.

Authors:  Y M Pu; H Ziffer
Journal:  J Med Chem       Date:  1995-02-17       Impact factor: 7.446

View more
  4 in total

1.  De Novo Synthesis of the DEF-Ring Stereotriad Core of the Veratrum Alkaloids.

Authors:  Matthew A Horwitz; Jacob G Robins; Jeffrey S Johnson
Journal:  J Org Chem       Date:  2020-04-30       Impact factor: 4.354

2.  Progress toward a Convergent, Asymmetric Synthesis of Jervine.

Authors:  Blane P Zavesky; Pedro De Jesús Cruz; Jeffrey S Johnson
Journal:  Org Lett       Date:  2020-04-14       Impact factor: 6.005

3.  Conformationally Locked Pyramidality Explains the Diastereoselectivity in the Methylation of trans-Fused Butyrolactones.

Authors:  Dániel Csókás; Juha H Siitonen; Petri M Pihko; Imre Pápai
Journal:  Org Lett       Date:  2020-04-27       Impact factor: 6.005

4.  Enantioselective Total Synthesis of (+)-Heilonine.

Authors:  Kyle J Cassaidy; Viresh H Rawal
Journal:  J Am Chem Soc       Date:  2021-09-29       Impact factor: 15.419

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.