Literature DB >> 18221132

Promising drugs against tuberculosis.

Marcus Vinícius Nora de Souza1.   

Abstract

Tuberculosis (TB) is an important public health problem worldwide due to AIDS epidemic, the advent of multidrug resistant strains (MDR) and the lack of new drugs in the market. TB is responsible for almost 3 millions deaths each year. According to WHO (World Health Organization), which declared tuberculosis a global health emergency in 1993, tuberculosis, without a coordinated control effort, will infect an estimated 1 billion people by 2020, killing 70 million. In spite of this problem, there is a lack of development of new TB drugs. For example, it has been nearly 35 years since the introduction of a new class of compounds for the treatment of TB. Thus, there is an urgent need for new drugs to fight against this disease. Considering that, this review aims promising drug candidates that are in development against TB.

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Year:  2006        PMID: 18221132     DOI: 10.2174/157489106775244163

Source DB:  PubMed          Journal:  Recent Pat Antiinfect Drug Discov        ISSN: 1574-891X


  8 in total

1.  Study of interactions between Mycobacterium tuberculosis proteins: SigK and anti-SigK.

Authors:  Vasavi Malkhed; Bargavi Gudlur; Bhargavi Kondagari; Ramasree Dulapalli; Uma Vuruputuri
Journal:  J Mol Model       Date:  2010-07-31       Impact factor: 1.810

2.  N'-[(E)-2-Meth-oxy-benzyl-idene]pyrazine-2-carbohydrazide.

Authors:  Marcus V N de Souza; Camilo H da Silva Lima; James L Wardell; Solange M S V Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-06-18

3.  Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis.

Authors:  Cristian Obiol-Pardo; Alex Cordero; Jaime Rubio-Martinez; Santiago Imperial
Journal:  J Mol Model       Date:  2009-11-15       Impact factor: 1.810

4.  N-(4-Bromo-phen-yl)pyrazine-2-carbox-amide.

Authors:  Marcelle de Lima Ferreira; Marcus V N de Souza; Solange M S V Wardell; James L Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

5.  (2S,3R)-tert-Butyl N-[4-(N-benzyl-4-fluoro-benzene-sulfonamido)-3-hy-droxy-1-phenyl-butan-2-yl]carbamate.

Authors:  Marcele Moreth; Marcus V N de Souza; James L Wardell; Solange M S V Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-21

6.  Bioactive Potential of Actinomycetes from Less Explored Ecosystems against Mycobacterium tuberculosis and Other Nonmycobacterial Pathogens.

Authors:  Radhakrishnan Manikkam; Gopikrishnan Venugopal; Balaji Subramaniam; Balagurunathan Ramasamy; Vanaja Kumar
Journal:  Int Sch Res Notices       Date:  2014-11-09

7.  Microwave-assisted solution-phase synthesis and DART-mass spectrometric monitoring of a combinatorial library of indolin-2,3-dione schiff bases with potential antimycobacterial activity.

Authors:  Tarek Aboul-Fadl; Hatem A Abdel-Aziz; Adnan Kadi; Pervez Ahmad; Tilal Elsaman; Mohamed W Attwa; Ibrahim A Darwish
Journal:  Molecules       Date:  2011-06-22       Impact factor: 4.411

8.  Aqueous Molecular Dynamics Simulations of the M. tuberculosis Enoyl-ACP Reductase-NADH System and Its Complex with a Substrate Mimic or Diphenyl Ethers Inhibitors.

Authors:  Camilo Henrique da Silva Lima; Ricardo Bicca de Alencastro; Carlos Roland Kaiser; Marcus Vinícius Nora de Souza; Carlos Rangel Rodrigues; Magaly Girão Albuquerque
Journal:  Int J Mol Sci       Date:  2015-10-07       Impact factor: 5.923

  8 in total

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