Literature DB >> 18220576

Metabolomics.

V S Gomase1, S S Changbhale, S A Patil, K V Kale.   

Abstract

Metabolomics is based on the simultaneous analysis of multiple low-molecular-weight metabolites from a given sample. The goals of metabolomics are to catalog and quantify the myriad small molecules found in biological fluids under different conditions. The metabolomics represents the collection of all metabolites in a biological organism, and metabolic profiling can give an instantaneous 'snapshot' of the physiology of that cell. Together with the other more established omics technologies, metabolomics will strengthen its claim to contribute to the detailed understanding of the in vivo function of gene products, biochemical analysis, regulatory networks and more ambitious, the mathematical description and simulation of the whole cell in the systems biology approach. This phenomenon will allow the construction of designer organisms for process application using biotransformation and fermentative approaches making effective use of single enzymes, whole microbial and even higher cells and allows the connection of data from genomics, proteomics to enables coordinating the timing of the analysis to physiologically important windows.

Mesh:

Year:  2008        PMID: 18220576     DOI: 10.2174/138920008783331149

Source DB:  PubMed          Journal:  Curr Drug Metab        ISSN: 1389-2002            Impact factor:   3.731


  14 in total

Review 1.  Database resources in metabolomics: an overview.

Authors:  Eden P Go
Journal:  J Neuroimmune Pharmacol       Date:  2009-05-07       Impact factor: 4.147

Review 2.  The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses.

Authors:  Natalie J Serkova; Theodore J Standiford; Kathleen A Stringer
Journal:  Am J Respir Crit Care Med       Date:  2011-06-16       Impact factor: 21.405

3.  Characterizing the intracellular distribution of metabolites in intact Chlamydia-infected cells by Raman and two-photon microscopy.

Authors:  Márta Szaszák; Jiun Chiun Chang; Weinan Leng; Jan Rupp; David M Ojcius; Anne Myers Kelley
Journal:  Microbes Infect       Date:  2013-03-27       Impact factor: 2.700

Review 4.  Metabolomics: a novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer's disease.

Authors:  Xu-Hua Xu; Yue Huang; Gang Wang; Sheng-Di Chen
Journal:  Neurosci Bull       Date:  2012-10-03       Impact factor: 5.203

5.  A breath of information: the volatilome.

Authors:  M Mansurova; Birgitta E Ebert; Lars M Blank; Alfredo J Ibáñez
Journal:  Curr Genet       Date:  2017-12-26       Impact factor: 3.886

Review 6.  Applications of mass spectrometry to lipids and membranes.

Authors:  Richard Harkewicz; Edward A Dennis
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

Review 7.  Tracer-based metabolomics: concepts and practices.

Authors:  W-N Paul Lee; Paulin N Wahjudi; Jun Xu; Vay Liang Go
Journal:  Clin Biochem       Date:  2010-08-14       Impact factor: 3.281

8.  A metabolomic approach to animal vitreous humor topographical composition: a pilot study.

Authors:  Emanuela Locci; Paola Scano; Maria Francesca Rosa; Matteo Nioi; Antonio Noto; Luigi Atzori; Roberto Demontis; Fabio De-Giorgio; Ernesto d'Aloja
Journal:  PLoS One       Date:  2014-05-20       Impact factor: 3.240

Review 9.  Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders.

Authors:  Sumit Sethi; Elisa Brietzke
Journal:  Int J Neuropsychopharmacol       Date:  2015-10-09       Impact factor: 5.176

Review 10.  Metabolomic analysis of human cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis diseases.

Authors:  Akram Safaei; Afsaneh Arefi Oskouie; Seyed Reza Mohebbi; Mostafa Rezaei-Tavirani; Mohammad Mahboubi; Maryam Peyvandi; Farshad Okhovatian; Mona Zamanian-Azodi
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2016
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