Literature DB >> 18212112

Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.

Christoph Ruckenstuhl1, Andrea Poschenel, Reinhard Possert, Pravas Kumar Baral, Karl Gruber, Friederike Turnowsky.   

Abstract

Saccharomyces cerevisiae squalene epoxidase contains two highly conserved motifs, 1 and 2, of unknown function. Amino acid substitutions in both regions reduce enzyme activity and/or alter allylamine sensitivity. In the homology model, these motifs flank the flavin adenine dinucleotide cofactor and form part of the interface between cofactor and substrate binding domains.

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Year:  2008        PMID： 18212112      PMCID： PMC2292544          DOI： 10.1128/AAC.01282-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  ERG1, encoding squalene epoxidase, is located on the right arm of chromosome VII of Saccharomyces cerevisiae.

Authors:  K M Landl; B Klösch; F Turnowsky
Journal:  Yeast       Date:  1996-05       Impact factor: 3.239

2.  Do salt bridges stabilize proteins? A continuum electrostatic analysis.

Authors:  Z S Hendsch; B Tidor
Journal:  Protein Sci       Date:  1994-02       Impact factor: 6.725

3.  Single amino acid exchanges in FAD-binding domains of squalene epoxidase of Saccharomyces cerevisiae lead to either loss of functionality or terbinafine sensitivity.

Authors:  C Ruckenstuhl; A Eidenberger; S Lang; F Turnowsky
Journal:  Biochem Soc Trans       Date:  2005-11       Impact factor: 5.407

4.  Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding.

Authors:  M H Eppink; H A Schreuder; W J Van Berkel
Journal:  Protein Sci       Date:  1997-11       Impact factor: 6.725

5.  Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis.

Authors:  Melody Germann; Christina Gallo; Timothy Donahue; Reza Shirzadi; Joseph Stukey; Silvia Lang; Christoph Ruckenstuhl; Simonetta Oliaro-Bosso; Virginia McDonough; Friederike Turnowsky; Gianni Balliano; Joseph T Nickels
Journal:  J Biol Chem       Date:  2005-08-24       Impact factor: 5.157

6.  Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene.

Authors:  Vlasta Klobucníková; Peter Kohút; Regina Leber; Sandra Fuchsbichler; Natascha Schweighofer; Friederike Turnowsky; Ivan Hapala
Journal:  Biochem Biophys Res Commun       Date:  2003-09-26       Impact factor: 3.575

7.  Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae.

Authors:  Regina Leber; Sandra Fuchsbichler; Vlasta Klobucníková; Natascha Schweighofer; Eva Pitters; Kathrin Wohlfarter; Mojca Lederer; Karina Landl; Christoph Ruckenstuhl; Ivan Hapala; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

8.  Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes.

Authors:  N S Ryder; M C Dupont
Journal:  Biochem J       Date:  1985-09-15       Impact factor: 3.857

9.  Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase.

Authors:  Hee-Kyoung Lee; Yi Feng Zheng; Xiao-Yi Xiao; Mei Bai; Jun Sakakibara; Teruo Ono; Glenn D Prestwich
Journal:  Biochem Biophys Res Commun       Date:  2004-02-27       Impact factor: 3.575

10.  Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.

Authors:  Christoph Ruckenstuhl; Silvia Lang; Andrea Poschenel; Armin Eidenberger; Pravas Kumar Baral; Peter Kohút; Ivan Hapala; Karl Gruber; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191
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