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Literature DB >> 18197348

Fluorine in medicinal chemistry.

Sophie Purser¹, Peter R Moore, Steve Swallow, Véronique Gouverneur.

Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 18197348 DOI： 10.1039/b610213c

Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564

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Cited

529 in total

1. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.

Authors: Vigneshwaran Namasivayam; Murugesan Vanangamudi; Victor G Kramer; Sonali Kurup; Peng Zhan; Xinyong Liu; Jacob Kongsted; Siddappa N Byrareddy
Journal: J Med Chem Date: 2018-12-27 Impact factor: 7.446

2. Silver-mediated trifluoromethylation of arenes using TMSCF3.

Authors: Yingda Ye; Shin Hee Lee; Melanie S Sanford
Journal: Org Lett Date: 2011-09-20 Impact factor: 6.005

3. Mechanistic and computational studies of oxidatively-induced aryl-CF3 bond-formation at Pd: rational design of room temperature aryl trifluoromethylation.

Authors: Nicholas D Ball; J Brannon Gary; Yingda Ye; Melanie S Sanford
Journal: J Am Chem Soc Date: 2011-04-22 Impact factor: 15.419

4. From bifunctional to trifunctional (tricomponent nucleophile-transition metal-lewis acid) catalysis: the catalytic, enantioselective α-fluorination of acid chlorides.

Authors: Jeremy Erb; Daniel H Paull; Travis Dudding; Lee Belding; Thomas Lectka
Journal: J Am Chem Soc Date: 2011-04-22 Impact factor: 15.419

5. Merging visible-light photocatalysis and transition-metal catalysis in the copper-catalyzed trifluoromethylation of boronic acids with CF3I.

Authors: Yingda Ye; Melanie S Sanford
Journal: J Am Chem Soc Date: 2012-05-24 Impact factor: 15.419

Fluorine in medicinal chemistry.

1. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.

2. Silver-mediated trifluoromethylation of arenes using TMSCF3.

3. Mechanistic and computational studies of oxidatively-induced aryl-CF3 bond-formation at Pd: rational design of room temperature aryl trifluoromethylation.

4. From bifunctional to trifunctional (tricomponent nucleophile-transition metal-lewis acid) catalysis: the catalytic, enantioselective α-fluorination of acid chlorides.

5. Merging visible-light photocatalysis and transition-metal catalysis in the copper-catalyzed trifluoromethylation of boronic acids with CF3I.

6. Visible light photocatalysis as a greener approach to photochemical synthesis.

7. Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists.

8. Optimization of propafenone analogues as antimalarial leads.

9. Engineered Fluorine Metabolism and Fluoropolymer Production in Living Cells.

10. Photocatalytic C-F Reduction and Functionalization.