Thomas M Gill1, Zhenchao Guo, Heather G Allore. 1. Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06504, USA. thomas.gill@yale.edu
Abstract
OBJECTIVES: To characterize distinct and clinically meaningful subtypes of disability, defined based on the number and duration of disability episodes, and to determine whether the incidence of these disability subtypes differ according to age, sex, or physical frailty. DESIGN: Prospective cohort study. SETTING: Greater New Haven, Connecticut. PARTICIPANTS: Seven hundred fifty-four community-living residents aged 70 and older and initially nondisabled in four essential activities of daily living. MEASUREMENTS: Disability was assessed during monthly telephone interviews for nearly 8 years; physical frailty was assessed during comprehensive home-based assessments at 18-month intervals. The incidence of five disability subtypes was determined within the context of the 18-month intervals in participants who were nondisabled at the start of the interval: transient, short-term, long-term, recurrent, and unstable. RESULTS: Incident disability was observed in 29.8% of the 18-month intervals. The most common subtypes were transient disability (9.7% of all intervals), defined as a single disability episode lasting only 1 month, and long-term disability (6.9%), defined as one or more disability episodes, with at least one lasting 6 or more months. Approximately one-quarter (24.7%) of all participants had two or more intervals with an incident disability subtype. Although there were no sex differences in the incidence rates for any of the subtypes, differences in rates were observed for each subtype according to age and physical frailty, with only one exception, and were especially large for long-term disability. CONCLUSION: The mechanisms underlying the different disability subtypes may differ. Additional research is warranted to evaluate the natural history, risk factors, and prognosis of the five disability subtypes.
OBJECTIVES: To characterize distinct and clinically meaningful subtypes of disability, defined based on the number and duration of disability episodes, and to determine whether the incidence of these disability subtypes differ according to age, sex, or physical frailty. DESIGN: Prospective cohort study. SETTING: Greater New Haven, Connecticut. PARTICIPANTS: Seven hundred fifty-four community-living residents aged 70 and older and initially nondisabled in four essential activities of daily living. MEASUREMENTS: Disability was assessed during monthly telephone interviews for nearly 8 years; physical frailty was assessed during comprehensive home-based assessments at 18-month intervals. The incidence of five disability subtypes was determined within the context of the 18-month intervals in participants who were nondisabled at the start of the interval: transient, short-term, long-term, recurrent, and unstable. RESULTS: Incident disability was observed in 29.8% of the 18-month intervals. The most common subtypes were transient disability (9.7% of all intervals), defined as a single disability episode lasting only 1 month, and long-term disability (6.9%), defined as one or more disability episodes, with at least one lasting 6 or more months. Approximately one-quarter (24.7%) of all participants had two or more intervals with an incident disability subtype. Although there were no sex differences in the incidence rates for any of the subtypes, differences in rates were observed for each subtype according to age and physical frailty, with only one exception, and were especially large for long-term disability. CONCLUSION: The mechanisms underlying the different disability subtypes may differ. Additional research is warranted to evaluate the natural history, risk factors, and prognosis of the five disability subtypes.
Authors: J M Guralnik; L Ferrucci; C F Pieper; S G Leveille; K S Markides; G V Ostir; S Studenski; L F Berkman; R B Wallace Journal: J Gerontol A Biol Sci Med Sci Date: 2000-04 Impact factor: 6.053
Authors: Thomas M Gill; Dorothy I Baker; Margaret Gottschalk; Peter N Peduzzi; Heather Allore; Amy Byers Journal: N Engl J Med Date: 2002-10-03 Impact factor: 91.245
Authors: Lauren E Ferrante; Margaret A Pisani; Terrence E Murphy; Evelyne A Gahbauer; Linda S Leo-Summers; Thomas M Gill Journal: JAMA Intern Med Date: 2015-04 Impact factor: 21.873
Authors: Fredric D Wolinsky; Padmaja Ayyagari; Theodore K Malmstrom; J Phillip Miller; Elena M Andresen; Mario Schootman; Douglas K Miller Journal: J Gerontol A Biol Sci Med Sci Date: 2013-12-13 Impact factor: 6.053