Literature DB >> 1819230

Genetic epidemiology of complex phenotypes.

N E Morton1, D C Shields, A Collins.   

Abstract

A theory is given for complex phenotypes represented by an ordered polychotomy separately for affected (as severity) and for normals (as diathesis), with consideration of history, ascertainment, sampling frames, and phenotype systems. Nonrandom selection of probands by severity is permitted. Both probit and logistic models are developed in a form compatible with segregation and/or linkage analysis. Probabilities are set out in detail in the Appendix. This approach avoids problems that have been encountered with quantitative traits and correlated phenotypes, although using this information.

Mesh：

Year:  1991        PMID： 1819230     DOI： 10.1111/j.1469-1809.1991.tb00857.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  13 in total

1.  Significance levels in complex inheritance.

Authors:  N E Morton
Journal:  Am J Hum Genet       Date:  1998-03       Impact factor: 11.025

2.  Logarithm of odds (lods) for linkage in complex inheritance.

Authors:  N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

3.  Comparison of parametric and nonparametric methods to map oligogenes by linkage.

Authors:  P Liò; N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

4.  Segregation analysis of NIDDM in Caucasian families.

Authors:  J T Cook; D C Shields; R C Page; J C Levy; A T Hattersley; J A Shaw; H A Neil; J S Wainscoat; R C Turner
Journal:  Diabetologia       Date:  1994-12       Impact factor: 10.122

5.  Evidence for Mendelian inheritance of serum IgE levels in Hispanic and non-Hispanic white families.

Authors:  F D Martinez; C J Holberg; M Halonen; W J Morgan; A L Wright; L M Taussig
Journal:  Am J Hum Genet       Date:  1994-09       Impact factor: 11.025

6.  Combined segregation and linkage analysis of Graves disease with a thyroid autoantibody diathesis.

Authors:  D C Shields; S Ratanachaiyavong; A M McGregor; A Collins; N E Morton
Journal:  Am J Hum Genet       Date:  1994-09       Impact factor: 11.025

Review 7.  [Personalized medicine in otology. The role of genetic diagnostics in patients with hearing impairment].

Authors:  N Friese; K Braun; M Müller; A Tropitzsch
Journal:  HNO       Date:  2015-06       Impact factor: 1.284

8.  Family studies of non-insulin-dependent diabetes mellitus in South Indians.

Authors:  M I McCarthy; G A Hitman; D C Shields; N E Morton; C Snehalatha; V Mohan; A Ramachandran; M Viswanathan
Journal:  Diabetologia       Date:  1994-12       Impact factor: 10.122

9.  Genetic epidemiology of early onset breast cancer.

Authors:  D Eccles; A Marlow; G Royle; A Collins; N E Morton
Journal:  J Med Genet       Date:  1994-12       Impact factor: 6.318

10.  Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.

Authors:  M I McCarthy; M Hitchins; G A Hitman; P Cassell; K Hawrami; N Morton; V Mohan; A Ramachandran; C Snehalatha; M Viswanathan
Journal:  Diabetologia       Date:  1993-07       Impact factor: 10.122
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