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Literature DB >> 16580969

Critical review of the role of HTS in drug discovery.

Ricardo Macarron.

Abstract

'A wise use of lead discovery tactics will distinguish successful drug discovery engines.'

Entities: Disease

Mesh：

Year: 2006 PMID： 16580969 DOI： 10.1016/j.drudis.2006.02.001

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

Keyword Cloud
Cited

48 in total

1. Molecular simulation methods in drug discovery: a prospective outlook.

Authors: Xavier Barril; F Javier Luque
Journal: J Comput Aided Mol Des Date: 2011-12-08 Impact factor: 3.686

Review 2. Therapeutic antibodies directed at G protein-coupled receptors.

Authors: Catherine J Hutchings; Markus Koglin; Fiona H Marshall
Journal: MAbs Date: 2010-11-01 Impact factor: 5.857

Review 3. Design and implementation of high throughput screening assays.

Authors: Ricardo Macarrón; Robert P Hertzberg
Journal: Mol Biotechnol Date: 2011-03 Impact factor: 2.695

Review 4. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors: David J Newman; Gordon M Cragg
Journal: J Nat Prod Date: 2012-02-08 Impact factor: 4.050

5. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.

Authors: Kerim Babaoglu; Anton Simeonov; John J Irwin; Michael E Nelson; Brian Feng; Craig J Thomas; Laura Cancian; M Paola Costi; David A Maltby; Ajit Jadhav; James Inglese; Christopher P Austin; Brian K Shoichet
Journal: J Med Chem Date: 2008-03-12 Impact factor: 7.446

Critical review of the role of HTS in drug discovery.

1. Molecular simulation methods in drug discovery: a prospective outlook.

Review 2. Therapeutic antibodies directed at G protein-coupled receptors.

Review 3. Design and implementation of high throughput screening assays.

Review 4. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

5. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.

Review 6. Microfluidics for drug discovery and development: from target selection to product lifecycle management.

Review 7. The influence of lead discovery strategies on the properties of drug candidates.

8. CONFIRM: connecting fragments found in receptor molecules.

9. A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.

10. Directed evolution: overcoming biology's limitations.