| Literature DB >> 18180359 |
Stephanie J Wallace1, Jian Li, Roger L Nation, Craig R Rayner, David Taylor, Deborah Middleton, Robert W Milne, Kingsley Coulthard, John D Turnidge.
Abstract
The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.Entities:
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Year: 2008 PMID: 18180359 PMCID: PMC2258545 DOI: 10.1128/AAC.01101-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191