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Literature DB >> 551317

A method for the routine assessment of fore- and hindlimb grip strength of rats and mice.

O A Meyer, H A Tilson, W C Byrd, M T Riley.

Abstract

A technique to measure the fore-and hindlimb grip strength of rats (adult and preweanling) and mice is described. the procedure utilizes inexpensive equipment, is rapid and efficient, and provides continuous level data. As a means of validating the sensitivity of the test, the effects of phenobarbital and chlordiazepoxide on the grip strength of adult Fisher strain and Sprague-Dawley derived adult rats were investigated. Dose-related decreases in fore- and hindlimb grip scores were observed in both strain of rats. The interanimal variability in this test was less in Fisher rats than in Sprague-Dawleys. The technique appears to have a great deal of potential in studies concerning the neuromotor effects of environmental and psychopharmacological agents.

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Year: 1979 PMID： 551317

Source DB: PubMed Journal: Neurobehav Toxicol ISSN： 0191-3581

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Cited

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A method for the routine assessment of fore- and hindlimb grip strength of rats and mice.

1. Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.

2. Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

3. Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.

4. Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

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