Literature DB >> 32071049

Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model.

Jiajun Liu1,2,3, Gwendolyn M Pais1,2, Sean N Avedissian4,5, Annette Gilchrist1,2,6, Andrew Lee7, Nathaniel J Rhodes1,2,3, Alan R Hauser6, Marc H Scheetz8,2,3.   

Abstract

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (P = 0.018) versus that of the controls (P = 0.99) and histopathological damage (P = 0.013). A three-compartment model best described the data (bias, 0.129 mg/liter; imprecision, 0.729 mg2/liter2; R 2, 0.652,). Area under the concentration-time curve at 24 h (AUC24) values were similar (P = 0.87). The thrice-daily dosing scheme resulted in the most PB-associated AKI in a rat model.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  acute kidney injury; animal model; colistin; pharmacodynamic; pharmacokinetic; polymyxin B; polymyxins; toxicodynamic; urinary biomarker

Mesh：

Substances：

Year:  2020        PMID： 32071049      PMCID： PMC7179599          DOI： 10.1128/AAC.02300-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  32 in total

Review 1.  Adverse reactions associated with systemic polymyxin therapy.

Authors:  Julie Ann Justo; John A Bosso
Journal:  Pharmacotherapy       Date:  2014-09-30       Impact factor: 4.705

2.  In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B therapy.

Authors:  Kady Phe; Yuman Lee; Patrick M McDaneld; Nishant Prasad; Taijun Yin; Deborah A Figueroa; William L Musick; Jessica M Cottreau; Ming Hu; Vincent H Tam
Journal:  Antimicrob Agents Chemother       Date:  2014-02-24       Impact factor: 5.191

3.  Melatonin attenuates colistin-induced nephrotoxicity in rats.

Authors:  Jumana M Yousef; Gong Chen; Prue A Hill; Roger L Nation; Jian Li
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

4.  Nephrotoxicity in Patients with or without Cystic Fibrosis Treated with Polymyxin B Compared to Colistin.

Authors:  Ryan L Crass; W Cliff Rutter; Donna R Burgess; Craig A Martin; David S Burgess
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.

Authors:  Vishal S Vaidya; Josef S Ozer; Frank Dieterle; Fitz B Collings; Victoria Ramirez; Sean Troth; Nagaraja Muniappa; Douglas Thudium; David Gerhold; Daniel J Holder; Norma A Bobadilla; Estelle Marrer; Elias Perentes; André Cordier; Jacky Vonderscher; Gérard Maurer; Peter L Goering; Frank D Sistare; Joseph V Bonventre
Journal:  Nat Biotechnol       Date:  2010-05       Impact factor: 54.908

6.  Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity.

Authors:  W C Prozialeck; V S Vaidya; J Liu; M P Waalkes; J R Edwards; P C Lamar; A M Bernard; X Dumont; J V Bonventre
Journal:  Kidney Int       Date:  2007-08-08       Impact factor: 10.612

Review 7.  Biomarkers of acute kidney injury.

Authors:  Vishal S Vaidya; Michael A Ferguson; Joseph V Bonventre
Journal:  Annu Rev Pharmacol Toxicol       Date:  2008       Impact factor: 13.820

8.  Single or multiple daily doses of aminoglycosides: a meta-analysis.

Authors:  M Barza; J P Ioannidis; J C Cappelleri; J Lau
Journal:  BMJ       Date:  1996-02-10

Review 9.  A simple practice guide for dose conversion between animals and human.

Authors:  Anroop B Nair; Shery Jacob
Journal:  J Basic Clin Pharm       Date:  2016-03

Review 10.  Antibiotic resistance: a rundown of a global crisis.

Authors:  Bilal Aslam; Wei Wang; Muhammad Imran Arshad; Mohsin Khurshid; Saima Muzammil; Muhammad Hidayat Rasool; Muhammad Atif Nisar; Ruman Farooq Alvi; Muhammad Aamir Aslam; Muhammad Usman Qamar; Muhammad Khalid Farooq Salamat; Zulqarnain Baloch
Journal:  Infect Drug Resist       Date:  2018-10-10       Impact factor: 4.003
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  3 in total

1.  Comparing the Population Pharmacokinetics of and Acute Kidney Injury Due to Polymyxin B in Chinese Patients with or without Renal Insufficiency.

Authors:  Peile Wang; Qiwen Zhang; Zhenfeng Zhu; Hui Pei; Min Feng; Tongwen Sun; Jing Yang; Xiaojian Zhang
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

2.  The Effect of Different Colistin Dosing Regimens on Nephrotoxicity: A Cohort Study.

Authors:  Michael Samarkos; Konstantinos Papanikolaou; Athena Sourdi; Nikolaos Paisios; Efstratios Mainas; Elisabeth Paramythiotou; Anastasia Antoniadou; Helen Sambatakou; Panayiotis Gargalianos-Kakolyris; Athanasios Skoutelis; George L Daikos
Journal:  Antibiotics (Basel)       Date:  2022-08-05

3.  Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity.

Authors:  Wenrui Sun; Binchuan Hu; Xiaoshan Zhang; Yuzhen Wang; Zheng Xiang; Guanyang Lin
Journal:  Drug Des Devel Ther       Date:  2021-02-16       Impact factor: 4.162
  3 in total

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