Literature DB >> 18173225

MRI detection of thrombin with aptamer functionalized superparamagnetic iron oxide nanoparticles.

Mehmet Veysel Yigit1, Debapriya Mazumdar, Yi Lu.   

Abstract

Design of smart MRI contrast agent based on superparamagnetic iron oxide nanoparticles and aptamers has been described for the detection of human alpha-thrombin protein. The contrast agent is based on the assembly of the aptamer functionalized nanoparticles in the presence of thrombin. A detectable change in MRI signal is observed with 25 nM thrombin in human serum. Changes were neither observed with control analytes, streptavidin, or bovine serum albumin, nor with inactive aptamer functionalized nanoparticles.

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Year:  2008        PMID： 18173225     DOI： 10.1021/bc7003928

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  43 in total

1.  Label-free catalytic and molecular beacon containing an abasic site for sensitive fluorescent detection of small inorganic and organic molecules.

Authors:  Panshu Song; Yu Xiang; Hang Xing; Zhaojuan Zhou; Aijun Tong; Yi Lu
Journal:  Anal Chem       Date:  2012-03-07       Impact factor: 6.986

2.  Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial.

Authors:  Mehmet V Yigit; Leyun Zhu; Marytheresa A Ifediba; Yong Zhang; Kevin Carr; Anna Moore; Zdravka Medarova
Journal:  ACS Nano       Date:  2010-12-31       Impact factor: 15.881

Review 3.  Molecular imaging with nucleic acid aptamers.

Authors:  H Hong; S Goel; Y Zhang; W Cai
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

Review 4.  Nucleic acid aptamers: clinical applications and promising new horizons.

Authors:  X Ni; M Castanares; A Mukherjee; S E Lupold
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

Review 5.  Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates.

Authors:  Jung Heon Lee; Mehmet V Yigit; Debapriya Mazumdar; Yi Lu
Journal:  Adv Drug Deliv Rev       Date:  2010-03-22       Impact factor: 15.470

Review 6.  Functional nucleic acid sensors.

Authors:  Juewen Liu; Zehui Cao; Yi Lu
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

Review 7.  Current progress of aptamer-based molecular imaging.

Authors:  Andrew Z Wang; Omid C Farokhzad
Journal:  J Nucl Med       Date:  2014-02-13       Impact factor: 10.057

8.  Label-free fluorescent aptamer sensor based on regulation of malachite green fluorescence.

Authors:  Weichen Xu; Yi Lu
Journal:  Anal Chem       Date:  2010-01-15       Impact factor: 6.986

Review 9.  Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

Authors:  Omid Veiseh; Jonathan W Gunn; Miqin Zhang
Journal:  Adv Drug Deliv Rev       Date:  2009-11-10       Impact factor: 15.470

10.  Target binding improves relaxivity in aptamer-gadolinium conjugates.

Authors:  Elyse D Bernard; Michael A Beking; Karunanithi Rajamanickam; Eve C Tsai; Maria C Derosa
Journal:  J Biol Inorg Chem       Date:  2012-08-19       Impact factor: 3.358
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