Literature DB >> 181730

The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.

A R Morgan, R L Cone, T M Elgert.   

Abstract

Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.

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Year:  1976        PMID： 181730      PMCID： PMC342976          DOI： 10.1093/nar/3.5.1139

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

1.  Defective superoxide production by granulocytes from patients with chronic granulomatous disease.

Authors:  J T Curnutte; D M Whitten; B M Babior
Journal:  N Engl J Med       Date:  1974-03-14       Impact factor: 91.245

2.  Concentration effect of bisulfite on the inactivation of transforming activity of DNA.

Authors:  M Inoue; H Hayatsu; H Tanooka
Journal:  Chem Biol Interact       Date:  1972-07       Impact factor: 5.192

3.  The univalent reduction of oxygen by reduced flavins and quinones.

Authors:  H P Misra; I Fridovich
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

Review 4.  Ascorbic acid and the glycosaminoglycans. An orthomolecular approach to cancer and other diseases.

Authors:  E Cameron; L Pauling
Journal:  Oncology       Date:  1973       Impact factor: 2.935

5.  Single-strand scissions induced in circular and linear lambda DNA by the presence of dithiothreitol and other reducing agents.

Authors:  V C Bode
Journal:  J Mol Biol       Date:  1967-05-28       Impact factor: 5.469

6.  The twisted circular form of polyoma viral DNA.

Authors:  J Vinograd; J Lebowitz; R Radloff; R Watson; P Laipis
Journal:  Proc Natl Acad Sci U S A       Date:  1965-05       Impact factor: 11.205

7.  Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure.

Authors:  A R Morgan; D E Pulleyblank
Journal:  Biochem Biophys Res Commun       Date:  1974-11-27       Impact factor: 3.575

8.  Generation of superoxide free radical during the autoxidation of thiols.

Authors:  H P Misra
Journal:  J Biol Chem       Date:  1974-04-10       Impact factor: 5.157

9.  Acceleration of the rate of deamidation of GlyArgAsnArgGly and of human transferrin by addition of L-ascorbic acid.

Authors:  A B Robinson; K Irving; M McCrea
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

10.  "Recommended daily allowances" for vitamin C.

Authors:  M L Yew
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205
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  15 in total

1.  Chemical cleavage of plasmid DNA by glutathione in the presence of Cu(II) ions. The Cu(II)-thiol system for DNA strand scission.

Authors:  C J Reed; K T Douglas
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

2.  Site-specific cleavage of supercoiled DNA by ascorbate/Cu(II).

Authors:  Y Wang; B Van Ness
Journal:  Nucleic Acids Res       Date:  1989-09-12       Impact factor: 16.971

Review 3.  Review: ethidium fluorescence assay. Part II. Enzymatic studies and DNA-protein interactions.

Authors:  A R Morgan; D H Evans; J S Lee; D E Pulleyblank
Journal:  Nucleic Acids Res       Date:  1979-10-10       Impact factor: 16.971

4.  Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy.

Authors:  Carlos Angelé-Martínez; Khanh Van T Nguyen; Fathima S Ameer; Jeffrey N Anker; Julia L Brumaghim
Journal:  Nanotoxicology       Date:  2017-03       Impact factor: 5.913

5.  Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeast Saccharomyces cerevisiae.

Authors:  Jessica A Zinskie; Arnab Ghosh; Brandon M Trainor; Daniel Shedlovskiy; Dimitri G Pestov; Natalia Shcherbik
Journal:  J Biol Chem       Date:  2018-07-18       Impact factor: 5.157

Review 6.  RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses.

Authors:  Jordan M Chapman; Joëlle K Muhlemann; Sheena R Gayomba; Gloria K Muday
Journal:  Chem Res Toxicol       Date:  2019-03-11       Impact factor: 3.739

7.  The inability of superoxide dismutase to inhibit the depolymerization of hyaluronic acid by ferrous ions and ascorbate.

Authors:  H Hofmann; O Schmut
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1980

8.  Effects of molecular oxygen, oxidation-reduction potential, and antioxidants upon in vitro replication of Treponema pallidum subsp. pallidum.

Authors:  D L Cox; B Riley; P Chang; S Sayahtaheri; S Tassell; J Hevelone
Journal:  Appl Environ Microbiol       Date:  1990-10       Impact factor: 4.792

9.  Characterization of immunological depression in mice exposed to normobaric oxygen.

Authors:  M Levacher-Place; M A Gougerot-Pocidalo; B Rouveix; L Kraus; J J Pocidalo
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330

10.  Potentiation of the biological activities of daunomycin and adriamycin by ascorbic acid and dimethylsulfoxide.

Authors:  M Marián; B Matkovics
Journal:  Experientia       Date:  1982-05-15
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