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Literature DB >> 18164205

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.

Christine M Wright¹, Raj J Chovatiya, Nora E Jameson, David M Turner, Guangyu Zhu, Stefan Werner, Donna M Huryn, James M Pipas, Billy W Day, Peter Wipf, Jeffrey L Brodsky.

Abstract

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70.

Entities: Chemical Disease Gene Species

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Year: 2007 PMID： 18164205 PMCID： PMC2330198 DOI： 10.1016/j.bmc.2007.12.014

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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