Interaction of ethanol and smoking on the pharmacokinetics and pharmacodynamics of psychotropic medications.

Ethanol and smoking are known to affect the pharmacokinetics and pharmacodynamics of many medications. This review focuses on the interactions between ethanol and smoking and psychotropic medications, in particular, antidepressants, anxiolytics, and neuroleptics. A discussion of the various mechanisms by which ethanol and smoking may exert their effects precedes a summary of specific interactions.