Literature DB >> 18093832

Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors.

Gang Shen1, Jinge Zhu, Anthony M Simpson, Dehua Pei.   

Abstract

Macrocyclic peptidyl hydroxamates were designed, synthesized, and evaluated as peptide deformylase (PDF) inhibitors. The most potent compound exhibited tight, slow-binding inhibition of Escherichia coli PDF (K(I)(*)=4.4 nM) and had potent antibacterial activity against Gram-positive bacterium Bacillus subtilis (MIC=2-4 microg/mL).

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Year:  2007        PMID： 18093832      PMCID： PMC2430612          DOI： 10.1016/j.bmcl.2007.12.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133.

Authors:  P T Rajagopalan; S Grimme; D Pei
Journal:  Biochemistry       Date:  2000-02-01       Impact factor: 3.162

2.  Structure-based design of a macrocyclic inhibitor for peptide deformylase.

Authors:  Xubo Hu; Kiet T Nguyen; Christophe L M J Verlinde; Wim G J Hol; Dehua Pei
Journal:  J Med Chem       Date:  2003-08-28       Impact factor: 7.446

3.  Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size.

Authors:  Xubo Hu; Kiet T Nguyen; Vernon C Jiang; Denene Lofland; Heinz E Moser; Dehua Pei
Journal:  J Med Chem       Date:  2004-09-23       Impact factor: 7.446

4.  Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands.

Authors:  M Scholl; S Ding; C W Lee; R H Grubbs
Journal:  Org Lett       Date:  1999-09-23       Impact factor: 6.005

5.  Continuous spectrophotometric assay of peptide deformylase.

Authors:  Y Wei; D Pei
Journal:  Anal Biochem       Date:  1997-07-15       Impact factor: 3.365

Review 6.  Peptide deformylase as an antibacterial target: a critical assessment.

Authors:  Jennifer A Leeds; Charles R Dean
Journal:  Curr Opin Pharmacol       Date:  2006-08-09       Impact factor: 5.547

Review 7.  Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.

Authors:  T Meinnel; Y Mechulam; S Blanquet
Journal:  Biochimie       Date:  1993       Impact factor: 4.079

8.  Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library.

Authors:  Y J Hu; Y Wei; Y Zhou; P T Rajagopalan; D Pei
Journal:  Biochemistry       Date:  1999-01-12       Impact factor: 3.162

9.  Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.

Authors:  D Chen; C Hackbarth; Z J Ni; C Wu; W Wang; R Jain; Y He; K Bracken; B Weidmann; D V Patel; J Trias; R J White; Z Yuan
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

10.  Alpha-substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents.

Authors:  R Jain; A Sundram; S Lopez; G Neckermann; C Wu; C Hackbarth; D Chen; W Wang; N S Ryder; B Weidmann; D Patel; J Trias; R White; Z Yuan
Journal:  Bioorg Med Chem Lett       Date:  2003-12-01       Impact factor: 2.823
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  1 in total

1.  Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.

Authors:  Alexander K Berg; Qingfeng Yu; Steven Y Qian; Manas K Haldar; D K Srivastava
Journal:  Biochim Biophys Acta       Date:  2009-11-14
  1 in total

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